Associations of change in body fat percentage with baseline body composition and diabetes remission after bariatric surgery

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2024-03-22 DOI:10.1002/oby.24003

Shaobo Li, Pin Zhang, Jianzhong Di, Xiaodong Han, Yinfang Tu, Di Yang, Rongrong Xu, Yunfeng Xiao, Jian Zhou, Yuqian Bao, Jun Yin, Haoyong Yu, Weiping Jia, Junfeng Han

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引用次数: 0

Abstract

Objective

The objective of this study was to determine the role of body fat percentage (BFP) changes in diabetes remission (DR) and the association between baseline body composition and its changes after bariatric surgery.

Methods

We analyzed 203 patients with type 2 diabetes who underwent Roux-en-Y gastric bypass. Body composition was measured using a gold-standard-derived predictive equation and magnetic resonance imaging. Body composition changes were calculated as 100 × (baseline value – follow-up value)/baseline value. We verified the results in a laparoscopic sleeve gastrectomy cohort with 311 patients.

Results

Compared with non-remission patients in the Roux-en-Y gastric bypass cohort, those who achieved DR showed a higher baseline fat-free mass index (FFMI) and experienced the most significant changes in BFP (p < 0.001). In comparative analyses, BFP changes were significantly better than BMI changes in identifying short- and long-term DR. Linear regression analysis identified FFMI as the most significant baseline variable correlated with BFP changes (p < 0.001). Baseline BMI was positively correlated with changes in BFP but negatively correlated with changes in FFMI. These findings were replicated in the laparoscopic sleeve gastrectomy cohort.

Conclusions

BFP changes determine DR after bariatric surgery, and baseline FFMI is crucial for BFP changes. A low initial BMI is associated with a smaller BFP reduction and greater FFMI loss after bariatric surgery.

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减肥手术后体脂百分比的变化与基线身体成分和糖尿病缓解之间的关系。

研究目的本研究旨在确定体脂率（BFP）变化在糖尿病缓解（DR）中的作用，以及减肥手术后基线身体成分与体脂率变化之间的关联：我们分析了203名接受Roux-en-Y胃旁路手术的2型糖尿病患者。我们使用黄金标准预测方程和磁共振成像测量了身体成分。身体成分变化的计算公式为 100 ×（基线值 - 随访值）/基线值。我们在311名腹腔镜袖带胃切除术患者中验证了这一结果：结果：与 Roux-en-Y 胃旁路术队列中未恢复的患者相比，达到 DR 的患者基线无脂肪质量指数（FFMI）较高，BFP 的变化最为显著（p 结论：BFP 的变化决定了减肥后的 DR：BFP 的变化决定了减肥手术后的 DR，而基线 FFMI 对 BFP 的变化至关重要。低初始体重指数与减肥手术后较小的 BFP 减少量和较大的 FFMI 减少量相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.

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