Evaluation of Regenerative Efficacy of Amnion and Chorion Membrane in Treatment of Mandibular Molar Furcation Defects: A Clinico-radiographic Study.

Q3 Dentistry

Journal of Contemporary Dental Practice Pub Date : 2024-02-01 DOI:10.5005/jp-journals-10024-3640

Siddharth Mallapragda, Radhika Gupta, Stuti Gupta, Himani Sharma, Saransh Srivastava, Anusha Raj

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Abstract

Aim: Amnion and chorion membranes possess unique inherited biological properties that enhance wound healing and may accelerate periodontal regeneration. The present study aims to evaluate and compare the efficacy of amnion and chorion membranes in the treatment of furcation defects.

Materials and methods: A total of 20 patients were selected and were randomly allocated to group I and group II with 10 subjects in each group. Amnion and chorion membranes are placental-derived membranes that accelerate regeneration by having natural growth factors with their antimicrobial and inflammation reduction properties. Group I was treated using bone grafting with decalcified freeze-dried bone allograft (DFDBA) and placement of amnion as a membrane for guided tissue regeneration (GTR) whereas group II was treated using bone grafting with DFDBA and placement of chorion as a membrane for GTR. The patients were followed for clinical and radiographic parameters and were evaluated between 3 and 6 months after surgery.

Result: In intragroup comparison, a significant difference was evident in both the groups for all the clinical and radiographic parameters within the groups. (p = 0.01) This means both amnion and chorion membranes showed statistically significant regenerative efficacy. In intergroup comparison, the results show that all the clinical parameters and radiographic parameters show no significant difference between the groups.

Conclusion: The amnion and chorion membranes had similar regenerative efficacy in combination with DFDBA in patients with buccal degree II furcation defects in mandibular molars.

Clinical significance: The amnion and chorion membranes have shown significant improvement in clinical and radiographic parameters when used for the treatment of buccal degree II furcation defects in mandibular molars. How to cite this article: Mallapragda S, Gupta R, Gupta S, et al. Evaluation of Regenerative Efficacy of Amnion and Chorion Membrane in Treatment of Mandibular Molar Furcation Defects: A Clinico-radiographic Study. J Contemp Dent Pract 2024;25(2):160-167.

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评估羊膜和绒毛膜治疗下颌磨牙毛面缺损的再生功效：临床放射学研究

目的：羊膜和绒毛膜具有独特的遗传生物学特性，可促进伤口愈合并加速牙周再生。本研究旨在评估和比较羊膜和绒毛膜治疗毛囊缺损的疗效：选取 20 名患者，随机分配到 I 组和 II 组，每组 10 人。羊膜和绒毛膜是胎盘膜，具有天然生长因子和抗菌消炎特性，可加速再生。第一组采用脱钙冻干异体骨（DFDBA）植骨，并将羊膜作为引导组织再生（GTR）膜；第二组采用脱钙冻干异体骨（DFDBA）植骨，并将绒毛膜作为引导组织再生（GTR）膜。术后 3 至 6 个月对患者的临床和影像学参数进行随访和评估：结果：在组内比较中，两组患者的所有临床和影像学参数均有明显差异（P = 0.01）。(p = 0.01)这意味着羊膜和绒毛膜都显示出统计学意义上的再生功效。在组间比较中，结果显示各组间的所有临床参数和影像学参数均无明显差异：结论：羊膜和绒毛膜联合 DFDBA 对下颌磨牙颊面Ⅱ度沟缺损患者具有相似的再生疗效：羊膜和绒毛膜用于治疗下颌磨牙颊面Ⅱ度窝沟缺损时，其临床和影像学参数均有显著改善。如何引用本文：Mallapragda S, Gupta R, Gupta S, et al. Evaluation of Regenerative Efficacy of Amnion and Chorion Membrane in Treatment of Mandibular Molar Furcation Defects：临床放射学研究。J Contemp Dent Pract 2024;25(2):160-167.

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来源期刊

Journal of Contemporary Dental Practice Dentistry-Dentistry (all)

CiteScore

1.80

自引率

0.00%

发文量

174

期刊介绍： The Journal of Contemporary Dental Practice (JCDP), is a peer-reviewed, open access MEDLINE indexed journal. The journal’s full text is available online at http://www.thejcdp.com. The journal allows free access (open access) to its contents. Articles with clinical relevance will be given preference for publication. The Journal publishes original research papers, review articles, rare and novel case reports, and clinical techniques. Manuscripts are invited from all specialties of dentistry i.e., conservative dentistry and endodontics, dentofacial orthopedics and orthodontics, oral medicine and radiology, oral pathology, oral surgery, orodental diseases, pediatric dentistry, implantology, periodontics, clinical aspects of public health dentistry, and prosthodontics.