Peritumoral MRI Radiomics Features Increase the Evaluation Efficiency for Response to Chemotherapy in Patients With Epithelial Ovarian Cancer

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-03-22 DOI:10.1002/jmri.29359

Yong'ai Li MD, PhD, Junming Jian PhD, Huijie Ge MD, Xin Gao PhD, Jinwei Qiang MD, PhD

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引用次数: 0

Abstract

Background

It remains unclear whether extracting peritumoral volume (PTV) radiomics features are useful tools for evaluating response to chemotherapy of epithelial ovarian cancer (EOC).

Purpose

To evaluate MRI radiomics signatures (RS) capturing subtle changes of PTV and their added evaluation performance to whole tumor volume (WTV) for response to chemotherapy in patients with EOC.

Study Type

Retrospective.

Population

219 patients aged from 15 to 79 years were enrolled.

Field Strength/Sequence

3.0 or 1.5T, axial fat-suppressed T2-weighted imaging (FS-T2WI), diffusion-weighted imaging (DWI), and contrast enhanced T1-weighted imaging (CE-T1WI).

Assessment

MRI features were extracted from the four axial sequences and six different volumes of interest (VOIs) (WTV and WTV + PTV (WPTV)) with different peritumor sizes (PS) ranging from 1 to 5 mm. Those features underwent preprocessing, and the most informative features were selected using minimum redundancy maximum relevance and least absolute shrinkage and selection operator to construct the RS. The optimal RS, with the highest area under the curve (AUC) of receiver operating characteristic was then integrated with independent clinical characteristics through multivariable logistic regression to construct the radiomics-clinical model (RCM).

Statistical Tests

Mann–Whitney U test, chi-squared test, DeLong test, log-rank test. P < 0.05 indicated a significant difference.

Results

All the RSs constructed on WPTV exhibited higher AUCs (0.720–0.756) than WTV (0.671). Of which, RS with PS = 2 mm displayed a significantly better performance (AUC = 0.756). International Federation of Gynecology and Obstetrics (FIGO) stage was identified as the exclusive independent clinical evaluation characteristic, and the RCM demonstrated higher AUC (0.790) than the RS, but without statistical significance (P = 0.261).

Data Conclusion

The radiomics features extracted from PTV could increase the efficiency of WTV radiomics for evaluating the chemotherapy response of EOC. The cut-off of 2 mm PTV was a reasonable value to obtain effective evaluation efficiency.

Level of Evidence

Technical Efficacy

Stage 2

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瘤周磁共振成像放射组学特征提高了上皮性卵巢癌患者化疗反应的评估效率

背景：提取瘤周体积（PTV）放射组学特征是否是评估上皮性卵巢癌（EOC）化疗反应的有用工具仍不清楚：目的：评估捕捉瘤周体积（PTV）细微变化的MRI放射组学特征（RS）及其对整个肿瘤体积（WTV）的附加评估性能，以评估EOC患者的化疗反应：研究对象：219名患者，年龄从15岁到79岁：场强/序列：3.0 或 1.5T，轴向脂肪抑制 T2 加权成像（FS-T2WI）、弥散加权成像（DWI）和对比增强 T1 加权成像（CE-T1WI）：从四个轴向序列和六个不同的感兴趣体（VOI）（WTV 和 WTV + PTV (WPTV)）中提取磁共振成像特征，肿瘤周围大小（PS）从 1 毫米到 5 毫米不等。对这些特征进行预处理后，使用最小冗余最大相关性和最小绝对收缩和选择算子选出信息量最大的特征，构建 RS。然后，通过多变量逻辑回归将接收器操作特征曲线下面积（AUC）最大的最佳 RS 与独立临床特征整合，构建放射肿瘤学-临床模型（RCM）：统计学检验： Mann-Whitney U检验、卡方检验、DeLong检验、log-rank检验。P 结果所有基于 WPTV 构建的 RS 的 AUC（0.720-0.756）均高于 WTV（0.671）。其中，PS = 2 mm 的 RS 表现明显更好（AUC = 0.756）。国际妇产科联盟（FIGO）分期被确定为唯一独立的临床评估特征，RCM的AUC（0.790）高于RS，但无统计学意义（P = 0.261）：数据结论：从PTV提取的放射组学特征可提高WTV放射组学评价EOC化疗反应的效率。2毫米PTV的临界值是获得有效评估效率的合理值：4 技术效率：第二阶段。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567