Prognostic biomarkers and clinical parameters in adults with atrial septal defect-related pulmonary arterial hypertension treated with sildenafil and beraprost combination therapy

IF 0.6 Q4 PEDIATRICS

PROGRESS IN PEDIATRIC CARDIOLOGY Pub Date : 2024-02-29 DOI:10.1016/j.ppedcard.2024.101720

Anudya Kartika Ratri , I. Gde Rurus Suryawan , Meity Ardiana , Andrianto , Stavros G. Drakos

{"title":"Prognostic biomarkers and clinical parameters in adults with atrial septal defect-related pulmonary arterial hypertension treated with sildenafil and beraprost combination therapy","authors":"Anudya Kartika Ratri , I. Gde Rurus Suryawan , Meity Ardiana , Andrianto , Stavros G. Drakos","doi":"10.1016/j.ppedcard.2024.101720","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Altered biological and environmental factors have been linked to the development of pulmonary vascular remodeling in pulmonary arterial hypertension (PAH) pathogenesis.</p></div><div><h3>Objectives</h3><p>We determined the association between prognostic biomarkers and clinical parameters of pulmonary arterial hypertension (PAH) in adult Atrial Septal Defect (ASD) patients with right heart failure who were treated with sildenafil and beraprost combination therapy.</p></div><div><h3>Methods</h3><p>We conducted an observational study using a cross-sectional design and examined the correlation between prognostic biomarkers (superoxide dismutase (SOD) and Platelet-derived growth factor-BB (PDGF-BB)) and clinical parameters (6 minute walking distance (6MWD) and echocardiography parameters (tricuspid annular plane systolic excursion/pulmonary artery systolic pressure (TAPSE/PASP)) in 41 adult patients with ASD diagnosed as pre-capillary pulmonary hypertension (WHO group 1) who were treated at the congenital outpatient clinic at Dr. Soetomo General Hospital Surabaya, Indonesia from October 1st to November 30th 2022. A Pearson correlation test was used to determine the correlation between normal distribution variables. Statistical analyses were done using SPSS software.</p></div><div><h3>Results</h3><p>The results indicated a moderately negative relationship between PDGF-BB and 6MWD (Pearson, <em>r</em> = −0.320, <em>p</em> = 0.041) and a medium significantly negative relationship between PDGF-BB and TAPSE/PASP (Pearson, <em>r</em> = −0.347, <em>p</em> = 0.026).</p></div><div><h3>Conclusions</h3><p>Lower circulating PDGF-BB is associated with better functional capacity and echocardiographic parameters in adult ASD-PAH patients receiving sildenafil and beraprost combination therapy. PDGF-BB may strongly be used as a treatment progress monitoring and prognostic biomarker.</p></div>","PeriodicalId":46028,"journal":{"name":"PROGRESS IN PEDIATRIC CARDIOLOGY","volume":null,"pages":null},"PeriodicalIF":0.6000,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PROGRESS IN PEDIATRIC CARDIOLOGY","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1058981324000183","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Altered biological and environmental factors have been linked to the development of pulmonary vascular remodeling in pulmonary arterial hypertension (PAH) pathogenesis.

Objectives

We determined the association between prognostic biomarkers and clinical parameters of pulmonary arterial hypertension (PAH) in adult Atrial Septal Defect (ASD) patients with right heart failure who were treated with sildenafil and beraprost combination therapy.

Methods

We conducted an observational study using a cross-sectional design and examined the correlation between prognostic biomarkers (superoxide dismutase (SOD) and Platelet-derived growth factor-BB (PDGF-BB)) and clinical parameters (6 minute walking distance (6MWD) and echocardiography parameters (tricuspid annular plane systolic excursion/pulmonary artery systolic pressure (TAPSE/PASP)) in 41 adult patients with ASD diagnosed as pre-capillary pulmonary hypertension (WHO group 1) who were treated at the congenital outpatient clinic at Dr. Soetomo General Hospital Surabaya, Indonesia from October 1st to November 30th 2022. A Pearson correlation test was used to determine the correlation between normal distribution variables. Statistical analyses were done using SPSS software.

Results

The results indicated a moderately negative relationship between PDGF-BB and 6MWD (Pearson, r = −0.320, p = 0.041) and a medium significantly negative relationship between PDGF-BB and TAPSE/PASP (Pearson, r = −0.347, p = 0.026).

Conclusions

Lower circulating PDGF-BB is associated with better functional capacity and echocardiographic parameters in adult ASD-PAH patients receiving sildenafil and beraprost combination therapy. PDGF-BB may strongly be used as a treatment progress monitoring and prognostic biomarker.

查看原文本刊更多论文

接受西地那非和贝前列素联合疗法的房间隔缺损相关肺动脉高压成人患者的预后生物标志物和临床参数

背景在肺动脉高压（PAH）发病机制中，生物和环境因素的改变与肺血管重塑的发展有关。目的我们确定了接受西地那非和贝前列素联合治疗的右心衰竭成人房室隔缺损（ASD）患者的预后生物标志物与肺动脉高压（PAH）临床参数之间的关联。方法我们采用横断面设计开展了一项观察性研究，并考察了预后生物标志物（超氧化物歧化酶（SOD）和血小板衍生生长因子-BB（PDGF-BB）与临床参数（6 分钟步行距离 (6MWD)）和超声心动图参数（三尖瓣环面收缩期偏移/肺动脉收缩压 (TAPSE/PASP)）之间的相关性。Soetomo综合医院（印度尼西亚泗水）先天性门诊治疗的41名被诊断为毛细血管前肺动脉高压（WHO第1组）的ASD成年患者（2022年10月1日至11月30日）。采用皮尔逊相关性检验来确定正态分布变量之间的相关性。结果表明，PDGF-BB 与 6MWD 呈中度负相关（Pearson，r = -0.320，p = 0.041），PDGF-BB 与 TAPSE/PASP 呈中度显著负相关（Pearson，r = -0.347，p = 0.026）。PDGF-BB可作为监测治疗进展和预后的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

PROGRESS IN PEDIATRIC CARDIOLOGY PEDIATRICS-

CiteScore

0.90

自引率

11.10%

发文量

审稿时长

75 days

期刊介绍： Progress in Pediatric Cardiology is an international journal of review presenting information and experienced opinion of importance in the understanding and management of cardiovascular diseases in children. Each issue is prepared by one or more Guest Editors and reviews a single subject, allowing for comprehensive presentations of complex, multifaceted or rapidly changing topics of clinical and investigative interest.