Burden of disease of respiratory syncytial virus in infants, young children and pregnant women and people.

Elissa M Abrams, Pamela Doyon-Plourde, Phaedra Davis, Nicholas Brousseau, Andrea Irwin, Winnie Siu, April Killikelly
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Abstract

Background: Passive immunization products for infants and pregnant women and people have sparked interest in understanding Canada's respiratory syncytial virus (RSV) burden. This rapid review examines RSV burden of disease in infants, young children and pregnant women and people.

Methods: Electronic databases were searched to identify studies and systematic reviews reporting data on outpatient visits, hospitalizations, intensive care unit admissions, deaths and preterm labour associated with RSV. We also contacted Canadian respiratory virus surveillance experts for additional data.

Results: Overall, 17 studies on infants and young children and 10 studies on pregnant women and people were included, in addition to primary surveillance data from one Canadian territory (Yukon). There were higher rates of medical utilization for infants than older children. Hospitalization rates were highest in infants under six months (more than 1% annually), with 5% needing intensive care unit admission, but mortality was low. Severe outcomes often occurred in healthy full-term infants and burden was higher than influenza. Respiratory syncytial virus attack rate was 10%-13% among pregnant women and people. Only one study found a higher hospitalization rate in pregnant women and people compared to non-pregnant women and people. Limited evidence was found on intensive care unit admission, death and preterm birth for pregnant women and people.

Conclusion: While risk of severe outcomes is larger in high-risk infants and children, healthcare burden is greatest in healthy term infants. The RSV severity for pregnant women and people appears to be similar to that for non-pregnant women and people.

呼吸道合胞病毒在婴幼儿、孕妇和人群中造成的疾病负担。
背景:针对婴儿、孕妇和人群的被动免疫产品引发了人们对了解加拿大呼吸道合胞病毒(RSV)负担的兴趣。本快速综述研究了婴儿、幼儿、孕妇和人群中 RSV 的疾病负担:我们搜索了电子数据库,以确定报告与 RSV 相关的门诊就诊、住院、重症监护室入院、死亡和早产数据的研究和系统综述。我们还联系了加拿大呼吸道病毒监测专家以获取更多数据:除了加拿大一个地区(育空地区)的主要监测数据外,我们还纳入了 17 项关于婴幼儿的研究和 10 项关于孕妇和人群的研究。婴幼儿的医疗使用率高于年长儿童。6 个月以下婴儿的住院率最高(每年超过 1%),5% 的婴儿需要入住重症监护室,但死亡率很低。健康的足月婴儿通常会出现严重后果,负担比流感更重。孕妇和人群的呼吸道合胞病毒感染率为 10%-13%。只有一项研究发现,与非孕妇和人群相比,孕妇和人群的住院率更高。关于孕妇和儿童入住重症监护室、死亡和早产的证据有限:结论:虽然高危婴儿和儿童出现严重后果的风险更大,但健康足月婴儿的医疗负担最重。孕妇和人群的 RSV 严重程度似乎与非孕妇和人群相似。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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