Effects of melatonin against experimentally induced apical periodontitis in rats

IF 1.3 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Australian Endodontic Journal Pub Date : 2024-03-21 DOI:10.1111/aej.12841

D. Kırmızı DDS, PhD, A. Ö. Sehirli PhD, S. Sayiner DVM, K. Orhan DDS, PhD, A. Sebai DDS, PhD, U. Aksoy DDS, PhD

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引用次数: 0

Abstract

Apical periodontitis is an inflammatory condition resulting from microbial invasion in the root canal system, causing periapical tissue destruction and bone resorption. This study investigated melatonin's effects, known for its antioxidant and anti-inflammatory properties, on experimentally induced apical periodontitis in rats. Three groups of rats were studied: control, apical periodontitis and apical periodontitis with melatonin treatment. Proinflammatory cytokines and enzyme levels in blood serum were measured, and micro-CT analysis assessed bone resorption. Results showed significantly elevated cytokines and enzyme levels in the apical periodontitis group compared to the control. However, in the melatonin-treated group, these levels were significantly reduced (p < 0.01–0.001). Micro-CT analysis indicated decreased periapical resorption cavity volume and surface area with melatonin treatment. This suggests that systemic melatonin administration can mitigate inflammation and reduce bone resorption in experimentally induced apical periodontitis in rats, potentially holding promise for human endodontic disease treatment pending further research.

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褪黑素对大鼠实验性根尖牙周炎的影响

根尖牙周炎是根管系统中微生物入侵引起的炎症，会造成根尖周组织破坏和骨吸收。褪黑素具有抗氧化和抗炎特性，本研究调查了褪黑素对实验诱导的大鼠根尖牙周炎的影响。研究了三组大鼠：对照组、根尖牙周炎组和接受褪黑素治疗的根尖牙周炎组。研究人员测量了血清中的促炎细胞因子和酶水平，并通过显微 CT 分析评估了骨吸收情况。结果显示，与对照组相比，根尖牙周炎组的细胞因子和酶水平明显升高。然而，在褪黑素治疗组，这些水平明显降低（p

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来源期刊

Australian Endodontic Journal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.50

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： The Australian Endodontic Journal provides a forum for communication in the different fields that encompass endodontics for all specialists and dentists with an interest in the morphology, physiology, and pathology of the human tooth, in particular the dental pulp, root and peri-radicular tissues. The Journal features regular clinical updates, research reports and case reports from authors worldwide, and also publishes meeting abstracts, society news and historical endodontic glimpses. The Australian Endodontic Journal is a publication for dentists in general and specialist practice devoted solely to endodontics. It aims to promote communication in the different fields that encompass endodontics for those dentists who have a special interest in endodontics.