Neurocognitive functioning among children and young people with Duchenne Muscular Dystrophy: A systematic review and meta-analysis.

IF 3 3区 心理学 Q2 CLINICAL NEUROLOGY
Clinical Neuropsychologist Pub Date : 2024-11-01 Epub Date: 2024-03-20 DOI:10.1080/13854046.2024.2324500
Jayne Gregg, Colin Wilson, David Curran, Donncha Hanna
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引用次数: 0

Abstract

Objective: The neurocognitive aspects of DMD have received less attention than the physiological sequalae. This study conducted a systematic review and meta-analysis of available literature on the neurocognitive profile of children and young people with DMD. Method: Five databases (EMBASE, Medline, PsycInfo, Scopus and Web of Science) and the grey literature was searched on 27th January 2023. Eligible articles were available in English and reported neurocognitive outcomes. Neurocognitive domains reported in a comparable way across a minimum of three studies were included. The neurocognitive domains of Full-Scale IQ (FSIQ), Verbal IQ (VIQ), Performance IQ (PIQ) and Working memory (WMI) derived from Wechsler scales and receptive vocabulary ability derived from the Peabody Picture Verbal Test (PPVT) were included. A single mean meta-analysis was completed. Results: Relevant data was extracted and presented for 38 eligible studies; 2 of which are from grey literature. Results suggest children with DMD perform around 1SD below non-clinical norms for FSIQ, PIQ, VIQ and WMI. Unlike VIQ, scores derived from the PPVT were within the non-clinical norms. Studies were of moderate - high quality, there was significant heterogeneity and no publication bias. Conclusion: A systematic review of working memory has not previously been completed, it appears that children with DMD perform around 1SD below the mean, like FSIQ, PIQVIQ and WMI. The PPVT is a measure of receptive verbal ability and caution is recommended around the interchangeability of PPVT scores and the wider construct of verbal intelligence.

患有杜兴氏肌肉萎缩症的儿童和青少年的神经认知功能:系统回顾和荟萃分析。
目的:与生理后遗症相比,DMD 的神经认知方面受到的关注较少。本研究对有关 DMD 儿童和青少年神经认知特征的现有文献进行了系统回顾和荟萃分析。研究方法于 2023 年 1 月 27 日检索了五个数据库(EMBASE、Medline、PsycInfo、Scopus 和 Web of Science)和灰色文献。符合条件的文章均为英文,并报告了神经认知结果。至少纳入三项研究中以可比方式报告的神经认知领域。包括韦氏量表中的全量表智商(FSIQ)、言语智商(VIQ)、表现智商(PIQ)和工作记忆(WMI)等神经认知领域,以及皮博迪图像言语测试(PPVT)中的接受词汇能力。完成了一项单一平均荟萃分析。结果提取并展示了 38 项符合条件的研究的相关数据;其中 2 项来自灰色文献。结果表明,DMD 儿童在 FSIQ、PIQ、VIQ 和 WMI 方面的表现比非临床常模低 1SD 左右。与 VIQ 不同的是,PPVT 的得分在非临床标准范围内。这些研究的质量为中等-高等,存在明显的异质性,且无发表偏倚。结论此前尚未完成对工作记忆的系统性回顾,DMD 儿童的表现似乎比平均水平低 1SD 左右,如 FSIQ、PIQVIQ 和 WMI。PPVT 是对接受性言语能力的测量,建议谨慎对待 PPVT 分数与更广泛的言语智能结构之间的互换性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical Neuropsychologist
Clinical Neuropsychologist 医学-临床神经学
CiteScore
8.40
自引率
12.80%
发文量
61
审稿时长
6-12 weeks
期刊介绍: The Clinical Neuropsychologist (TCN) serves as the premier forum for (1) state-of-the-art clinically-relevant scientific research, (2) in-depth professional discussions of matters germane to evidence-based practice, and (3) clinical case studies in neuropsychology. Of particular interest are papers that can make definitive statements about a given topic (thereby having implications for the standards of clinical practice) and those with the potential to expand today’s clinical frontiers. Research on all age groups, and on both clinical and normal populations, is considered.
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