Dietary Intake of Antioxidant Vitamins and Its Relation to the Progression of Chronic Kidney Disease in Adults With Preserved Renal Function

IF 3.4 3区医学 Q2 NUTRITION & DIETETICS

Journal of Renal Nutrition Pub Date : 2024-09-01 DOI:10.1053/j.jrn.2024.03.005

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引用次数: 0

Abstract

Objective

It is expected that antioxidants contribute to slow the progression of chronic kidney disease (CKD). However, there are no data on the protective effect of dietary antioxidant vitamins on CKD. The purpose of study was to evaluate the renoprotective effect of dietary antioxidant vitamins in the general population.

Design and Methods

The study participants were 127,081 Korean adults with preserved renal function with estimated glomerular filtration rate ≥60 mL/min/1.73 m². They were categorized into 3 groups by tertile levels of dietary antioxidant vitamins intake including vitamins C, E, and A. Cox proportional hazard assumption was used to calculate multivariable hazard ratios and 95% confidence interval for the incident moderate to severe CKD (adjusted hazard ratio [95% confidence interval]) according to tertile levels of dietary intake of antioxidant vitamins. Subgroup analysis was conducted to evaluate the risk of progression from normal to mildly decreased renal function, and from mildly decreased renal function to moderate to severe CKD.

Results

The risk of moderate to severe CKD was not significantly associated with the third tertile of dietary antioxidant vitamin intake including vitamin C (1.02 [0.78-1.34]), E (0.96 [0.73-1.27]), and A (0.98 [0.74-1.29]). Additionally, any tertile groups didn't show the significant association with the risk of moderate to severe CKD. Subgroup analysis also didn't show the decreased risk of progression from normal to mildly decreased renal function, and from mildly decreased renal function to moderate to severe CKD in any tertile groups.

Conclusion

Dietary intake of vitamins C, E, and A was not significantly associated with the risk of CKD progression.

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肾功能保持良好的成年人抗氧化维生素的膳食摄入量及其与慢性肾病进展的关系。

目的：抗氧化剂有望减缓慢性肾脏病（CKD）的进展。然而，目前还没有关于膳食抗氧化维生素对慢性肾脏病的保护作用的数据。本研究旨在评估膳食抗氧化维生素对普通人群肾脏的保护作用：研究对象为 127,081 名韩国成年人，他们的肾功能保持良好，eGFR ≥ 60 ml/min/1.73 m2。根据膳食中抗氧化维生素（包括维生素C、E和A）摄入量的三等分水平，将他们分为三组。根据膳食中抗氧化维生素摄入量的三等分水平，采用Cox比例危险假设计算中重度CKD的多变量危险比（HRs）和95%置信区间（95% CI）（调整HR [95% CI]）。我们还进行了分组分析，以评估肾功能从正常发展到轻度下降以及从轻度下降发展到中重度慢性肾功能衰竭的风险：结果：中度至重度慢性肾功能衰竭的风险与膳食抗氧化维生素摄入量的第三三分位数（包括维生素 C (1.02 [0.78 - 1.34])、维生素 E (0.96 [0.73 - 1.27])和维生素 A (0.98 [0.74 - 1.29])）无明显相关性。此外，任何三等分组与中度至重度慢性肾脏病的风险均无明显关联。亚组分析也未显示任何三等分组从肾功能正常到轻度肾功能减退，以及从轻度肾功能减退到中重度 CKD 的风险降低：结论：膳食中维生素 C、E 和 A 的摄入量与慢性肾功能衰竭恶化的风险无明显关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Renal Nutrition 医学-泌尿学与肾脏学

CiteScore

5.70

自引率

12.50%

发文量

146

审稿时长

6.7 weeks

期刊介绍： The Journal of Renal Nutrition is devoted exclusively to renal nutrition science and renal dietetics. Its content is appropriate for nutritionists, physicians and researchers working in nephrology. Each issue contains a state-of-the-art review, original research, articles on the clinical management and education of patients, a current literature review, and nutritional analysis of food products that have clinical relevance.