Severe acute respiratory syndrome coronavirus-2-related and imputable deaths in children: results from the French pediatric national registry.

IF 6.1 2区 医学 Q1 PEDIATRICS
World Journal of Pediatrics Pub Date : 2024-06-01 Epub Date: 2024-03-20 DOI:10.1007/s12519-023-00791-x
Marguerite Lockhart-Bouron, Noémie Vanel, Michael Levy, Anaïs R Briant, Etienne Javouhey, Sophie Breinig, Julia Dina, Marion Caseris, François Angoulvant, Stéphane Leteurtre, Morgan Recher, David W Brossier
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引用次数: 0

Abstract

Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for an important mortality rate worldwide. We aimed to evaluate the actual imputability of SARS-CoV-2 on the mortality rate associated with SARS-CoV-2-related illnesses in the pediatric intensive care unit (PICU). Secondary objectives were to identify risk factors for death.

Methods: This national multicenter comparative study comprised all patients under 18 years old with positive SARS-CoV-2 polymerase chain reactions (PCRs) [acute corona virus disease 2019 (COVID-19) or incidental SARS-CoV-2 infection] and/or pediatric inflammatory multisystem syndrome (PIMS) recorded in the French PICU registry (PICURe) between September 1, 2021, and August 31, 2022. Included patients were classified and compared according to their living status at the end of their PICU stay. Deceased patients were evaluated by four experts in the field of pediatric infectiology and/or pediatric intensive care. The imputability of SARS-CoV-2 as the cause of death was classified into four categories: certain, very probable, possible, or unlikely, and was defined by any of the first three categories.

Results: There were 948 patients included of which 43 died (4.5%). From this, 26 deaths (67%) could be attributed to SARS-CoV-2 infection, with an overall mortality rate of 2.8%. The imputability of death to SARS-CoV-2 was considered certain in only one case (0.1%). Deceased patients suffered more often from comorbidities, especially heart disease, neurological disorders, hematological disease, cancer, and obesity. None of the deceased patients were admitted for pediatric inflammatory multisystem syndrome (PIMS). Mortality risk factors were male gender, cardiac comorbidities, cancer, and acute respiratory distress syndrome.

Conclusions: SARS-CoV-2 mortality in the French pediatric population was low. Even though the imputability of SARS-CoV-2 on mortality was considered in almost two-thirds of cases, this imputability was considered certain in only one case.

与严重急性呼吸系统综合征冠状病毒-2 相关的儿童死亡病例和可归因的死亡病例:法国儿科全国登记处的结果。
背景:严重急性呼吸系统综合征冠状病毒-2(SARS-CoV-2严重急性呼吸系统综合征冠状病毒-2(SARS-CoV-2)在全球范围内造成了严重的死亡率。我们的目的是评估 SARS-CoV-2 对儿科重症监护病房(PICU)中与 SARS-CoV-2 相关疾病的死亡率的实际影响。次要目标是确定死亡的风险因素:这项全国性多中心比较研究包括 2021 年 9 月 1 日至 2022 年 8 月 31 日期间在法国 PICU 登记处 (PICURe) 登记的所有 SARS-CoV-2 聚合酶链反应 (PCR) 阳性的 18 岁以下患者[2019 年急性日冕病毒病 (COVID-19) 或 SARS-CoV-2 偶发感染]和/或儿科多系统炎症综合征 (PIMS)。根据 PICU 结束时患者的生存状况,对纳入的患者进行分类和比较。死亡患者由四位儿科感染学和/或儿科重症监护领域的专家进行评估。SARS-CoV-2作为死因的可能性分为四类:确定、非常可能、可能或不可能,并以前三类中的任何一类作为定义:结果:共纳入 948 名患者,其中 43 人死亡(4.5%)。其中 26 例死亡(67%)可归因于 SARS-CoV-2 感染,总死亡率为 2.8%。只有一例(0.1%)死亡病例被确定为感染了 SARS-CoV-2。死亡患者多有合并症,尤其是心脏病、神经系统疾病、血液病、癌症和肥胖症。死亡患者中没有人因小儿多系统炎症综合征(PIMS)而入院。死亡风险因素包括男性、心脏病、癌症和急性呼吸窘迫综合征:结论:法国儿科 SARS-CoV-2 死亡率较低。尽管在近三分之二的病例中,SARS-CoV-2 对死亡率的影响被认为是不可归因的,但只有一个病例的这种不可归因性被认为是确定的。
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来源期刊
World Journal of Pediatrics
World Journal of Pediatrics 医学-小儿科
CiteScore
10.50
自引率
1.10%
发文量
592
审稿时长
2.5 months
期刊介绍: The World Journal of Pediatrics, a monthly publication, is dedicated to disseminating peer-reviewed original papers, reviews, and special reports focusing on clinical practice and research in pediatrics. We welcome contributions from pediatricians worldwide on new developments across all areas of pediatrics, including pediatric surgery, preventive healthcare, pharmacology, stomatology, and biomedicine. The journal also covers basic sciences and experimental work, serving as a comprehensive academic platform for the international exchange of medical findings.
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