The Therapeutic Effect of Buyang Huanwu Decoction on Mild Cognitive Impairment (MCI) in Patients with Diabetes.

IF 1.7 4区医学 Q4 NEUROSCIENCES

International Journal of Neuroscience Pub Date : 2025-07-01 Epub Date: 2024-04-04 DOI:10.1080/00207454.2024.2334367

Ximing Cui, Shuang Wang, Shunjiang Xu, Lina Wang, Shanshan Dong, Rui Zhang, Zhaoyu Gao, Lei Jiang, Tingting Shen, Yingying Guo, Huimin Zhou

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引用次数: 0

Abstract

Objective: This study aims to comprehensively verify the efficacy of Buyang Huanwu Decoction in improving cognitive function in patients with diabetes.

Methods: Patients clinically diagnosed with mild cognitive impairment (MCI) assigned to either the placebo group or the Buyang Huanwu Decoction group. After strict screening and exclusions, a total of 156 participants completed the clinical trial, with 76 in the placebo group and 80 in the Buyang Huanwu Decoction group.

Results: After treatment, Buyang Huanwu Decoction group showed higher Mini-Mental State Examination and Montreal Cognitive Assessment scores compared to placebo (p < 0.05). Memory and Executive Screening, Boston Naming Test, and Animal Fluency Test scores were also higher in the treatment group (p < 0.05). No significant differences were found in DST and CDT scores (p > 0.05). Trail Making Test scores were lower in the treatment group (p < 0.05). No significant difference was observed between the two groups in terms of complications (p > 0.05).

Conclusion: Patients receiving Buyang Huanwu Decoction treatment demonstrated improvement in cognitive function, showing positive effects and providing preliminary evidence for the role of Buyang Huanwu Decoction in improving cognitive function in patients with diabetes. This suggests its potential for clinical application and further promotion.

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步阳黄酒煎剂对糖尿病患者轻度认知功能障碍（MCI）的治疗作用

研究目的本研究旨在全面验证步阳黄芪汤对改善糖尿病患者认知功能的疗效：临床诊断为轻度认知障碍（MCI）的患者被分配到安慰剂组或步阳黄芪煎剂组。经过严格筛选和排除，共有156人完成了临床试验，其中安慰剂组76人，步阳黄酒煎剂组80人：结果：治疗后，布央黄芪煎剂组的迷你精神状态检查和蒙特利尔认知评估得分均高于安慰剂组（P < 0.05）。治疗组的记忆力和执行力筛查、波士顿命名测试和动物流畅性测试得分也更高（P < 0.05）。DST 和 CDT 分数无明显差异（P > 0.05）。治疗组的路径制作测验分数较低（P < 0.05）。两组在并发症方面无明显差异（P > 0.05）：结论：接受步阳黄酒煎剂治疗的患者认知功能有所改善，显示出积极的效果，为步阳黄酒煎剂在改善糖尿病患者认知功能方面的作用提供了初步证据。这表明其具有临床应用和进一步推广的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Neuroscience 医学-神经科学

CiteScore

5.10

自引率

0.00%

发文量

132

审稿时长

2 months

期刊介绍： The International Journal of Neuroscience publishes original research articles, reviews, brief scientific reports, case studies, letters to the editor and book reviews concerned with problems of the nervous system and related clinical studies, epidemiology, neuropathology, medical and surgical treatment options and outcomes, neuropsychology and other topics related to the research and care of persons with neurologic disorders. The focus of the journal is clinical and transitional research. Topics covered include but are not limited to: ALS, ataxia, autism, brain tumors, child neurology, demyelinating diseases, epilepsy, genetics, headache, lysosomal storage disease, mitochondrial dysfunction, movement disorders, multiple sclerosis, myopathy, neurodegenerative diseases, neuromuscular disorders, neuropharmacology, neuropsychiatry, neuropsychology, pain, sleep disorders, stroke, and other areas related to the neurosciences.