Apolipoprotein E is a Potential Biomarker for Predicting Cancer Prognosis and is Correlated with Immune Infiltration

IF 2.7 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

OncoTargets and therapy Pub Date : 2024-03-19 DOI:10.2147/ott.s447319

Jinji Chen, Herong Zhu, Shaohua Chen, Hua Mi

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引用次数: 0

Abstract

Background: Apolipoprotein E (APOE) is a polymorphic protein that plays a role in lipoprotein transformation and metabolism. It is involved in numerous physiological processes within the body and is closely associated with tumor growth and metastasis. However, the role of APOE in pan-cancer has yet to be evaluated. Therefore, studying the association between APOE and various cancer types is crucial for providing a basis for individualized treatment strategies and clinical prognosis assessment.
Methods: We investigated the diagnostic and prognostic significance of APOE across 33 tumor types, as well as its correlation with tumor mutation burden (TMB) and microsatellite instability (MSI). Additionally, we employed the ESTIMATE and CIBERSORT algorithms to analyze the potential impact of APOE on the immune system. Furthermore, gene set enrichment analysis (GSEA) was conducted to explore its underlying physiological function.
Results: Based on observations from a pan-cancer dataset, APOE expression was significantly different between cancer and normal tissues, and was simultaneously associated with survival outcomes in terms of cancer type, clinical annotation, TMB, MSI, and TICs abundance. In addition, the results also showed that expression of APOE may respond to a variety of cancer chemotherapy.
Conclusion: The findings from this study strongly indicate a close association between APOE and tumor development. Moreover, APOE shows promise as a potential biomarker for predicting prognosis and response to immunotherapy in patients with pan-cancer.

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载脂蛋白 E 是预测癌症预后的潜在生物标记物，与免疫渗透相关

背景：载脂蛋白 E（APOE）是一种多态蛋白，在脂蛋白转化和代谢中发挥作用。它参与体内许多生理过程，并与肿瘤的生长和转移密切相关。然而，APOE 在泛癌症中的作用还有待评估。因此，研究 APOE 与各种癌症类型之间的关联对于为个体化治疗策略和临床预后评估提供依据至关重要：我们研究了 33 种肿瘤类型中 APOE 的诊断和预后意义，以及它与肿瘤突变负荷（TMB）和微卫星不稳定性（MSI）的相关性。此外，我们还采用了ESTIMATE和CIBERSORT算法来分析APOE对免疫系统的潜在影响。此外，我们还进行了基因组富集分析（GSEA），以探索其潜在的生理功能：结果：根据对泛癌症数据集的观察，APOE的表达在癌症组织和正常组织之间存在显著差异，并同时与癌症类型、临床注释、TMB、MSI和TICs丰度等生存结果相关。此外，研究结果还表明，APOE的表达可能会对多种癌症化疗产生反应：结论：这项研究的结果有力地表明了 APOE 与肿瘤发生之间的密切联系。此外，APOE有望成为预测泛癌症患者预后和对免疫疗法反应的潜在生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

OncoTargets and therapy BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ONCOLOGY

CiteScore

9.70

自引率

0.00%

发文量

221

审稿时长

1 months

期刊介绍： OncoTargets and Therapy is an international, peer-reviewed journal focusing on molecular aspects of cancer research, that is, the molecular diagnosis of and targeted molecular or precision therapy for all types of cancer. The journal is characterized by the rapid reporting of high-quality original research, basic science, reviews and evaluations, expert opinion and commentary that shed novel insight on a cancer or cancer subtype. Specific topics covered by the journal include: -Novel therapeutic targets and innovative agents -Novel therapeutic regimens for improved benefit and/or decreased side effects -Early stage clinical trials Further considerations when submitting to OncoTargets and Therapy: -Studies containing in vivo animal model data will be considered favorably. -Tissue microarray analyses will not be considered except in cases where they are supported by comprehensive biological studies involving multiple cell lines. -Biomarker association studies will be considered only when validated by comprehensive in vitro data and analysis of human tissue samples. -Studies utilizing publicly available data (e.g. GWAS/TCGA/GEO etc.) should add to the body of knowledge about a specific disease or relevant phenotype and must be validated using the authors’ own data through replication in an independent sample set and functional follow-up. -Bioinformatics studies must be validated using the authors’ own data through replication in an independent sample set and functional follow-up. -Single nucleotide polymorphism (SNP) studies will not be considered.