Wood cauliflower mushroom (Sparassis crispa) suppresses the body weight and visceral fat increased by ovariectomy in mice

IF 6.2 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY
Ryoken Aoki , Yasuo Watanabe , Yuki Sakai , Megumi Furukawa , Takahiro Shigetomi , Chen Jiun Rong , Nobuo Izumo
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Abstract

Sparassis crispa, an edible mushroom, has been reported to show many kinds of physiological functions. The present paper focused on reducing body weight, subcutaneous fat, and visceral fat gain in ovariectomized (OVX) mice. Using the fruiting body powder of the indoor cultivation S. crispa (IT S. crispa: ITSc), one week after the OVX, ITSc was administered to two OVX groups by per os (p.o). In the sham group, 10 mL/kg water and 10 mL/kg saline were administered by p.o. and subcutaneous adm, respectively. OVX groups were divided into four groups. These treatments were performed on animals 6 days a week for 8 weeks. Subcutaneous and visceral fat measurements were performed under inhalation anesthesia with isoflurane using a Latheta LCT-200 X-ray CT system. The biochemical markers and the mRNA expression levels of the PPARγ, adiponectin, TNF-α, PPARα, and leptin were measured. Significant increases in body weight, fat ratio, and glucose levels were detected in OVX mice compared to sham mice. These increases were significantly blocked by ITSc, but not estradiol. Furthermore, ITSc treatment significantly increased adiponectin and leptin levels in adipose tissue. These results suggest that ITSc improves lipid abnormalities due to the less activity of women's ovary function, excluding estrogen functions.

Abstract Image

木花菇(Sparassis crispa)可抑制小鼠因卵巢切除而增加的体重和内脏脂肪
据报道,一种食用菌 Sparassis crispa 具有多种生理功能。本文的研究重点是降低卵巢切除(OVX)小鼠的体重、皮下脂肪和内脏脂肪的增加。在卵巢切除一周后,使用室内栽培的松柏子实体粉末(IT S. crispa:ITSc),对两组卵巢切除小鼠进行经口(p.o)给药。假手术组则分别通过口服和皮下注射 10 mL/kg 水和 10 mL/kg 生理盐水。卵巢切除组分为四组。对动物进行每周 6 天、为期 8 周的上述治疗。皮下脂肪和内脏脂肪的测量是在异氟烷吸入麻醉下使用 Latheta LCT-200 X 射线 CT 系统进行的。测量了生化指标和 PPARγ、脂肪连素、TNF-α、PPARα 和瘦素的 mRNA 表达水平。与假小鼠相比,OVX 小鼠的体重、脂肪比率和血糖水平均显著增加。ITSc 能明显阻止这些增加,但雌二醇不能。此外,ITSc 还能明显提高脂肪组织中的脂肪连素和瘦素水平。这些结果表明,由于女性卵巢功能(不包括雌激素功能)活动减少,ITSc 可改善血脂异常。
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来源期刊
Current Research in Food Science
Current Research in Food Science Agricultural and Biological Sciences-Food Science
CiteScore
7.40
自引率
3.20%
发文量
232
审稿时长
84 days
期刊介绍: Current Research in Food Science is an international peer-reviewed journal dedicated to advancing the breadth of knowledge in the field of food science. It serves as a platform for publishing original research articles and short communications that encompass a wide array of topics, including food chemistry, physics, microbiology, nutrition, nutraceuticals, process and package engineering, materials science, food sustainability, and food security. By covering these diverse areas, the journal aims to provide a comprehensive source of the latest scientific findings and technological advancements that are shaping the future of the food industry. The journal's scope is designed to address the multidisciplinary nature of food science, reflecting its commitment to promoting innovation and ensuring the safety and quality of the food supply.
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