Two new lignans from the fresh roots of Zhongsheng No.1 Rehmannia glutinosa

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-03-19 DOI:10.1016/j.phytol.2024.03.005

Xiang-Da Li , Yan-Gang Cao , Yu-Han Zhang , Ying-Jie Ren , Meng-Nan Zeng , Yan-Ling Liu , Xu Chen , Xin-Yi Ma , Bing-Xian Zhao , Xiao-Ke Zheng , Wei-Sheng Feng

引用次数: 0

Abstract

Two new undescribed compounds, jiofuran acid A (1) and 8′-hydroxyl episesaminone (2), together with seven known compounds (3–9) were isolated from the fresh roots of Zhongsheng No.1 Rehmannia glutinosa. Their structures were established by spectroscopic techniques (HR-ESI-MS, 1D NMR, 2D NMR), and absolute configurations were resolved by comparing their experimental and calculated ECD spectra. Bioassay results demonstrated compounds 1–3 exhibited the obvious anti-pulmonary fibrosis activity.

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中生 1 号地黄鲜根中的两种新木脂素

从中生 1 号地黄的新鲜根中分离出了两个未曾描述过的新化合物：九呋喃酸 A (1)和 8′-羟基表异酰胺酮 (2)，以及七个已知化合物 (3-9)。通过光谱技术（HR-ESI-MS、1D NMR、2D NMR）确定了它们的结构，并通过比较它们的实验和计算 ECD 光谱解析了它们的绝对构型。生物测定结果表明，1-3 号化合物具有明显的抗肺纤维化活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.

Two new lignans from the fresh roots of Zhongsheng No.1 Rehmannia glutinosa

Abstract

Two new lignans from the fresh roots of Zhongsheng No.1 Rehmannia glutinosa