Ferritin: Significance in viral infections.

IF 9 2区 医学 Q1 VIROLOGY
Xia Zhao, Yuntao Zhou, Yong Zhang, Yan Zhang
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Abstract

As an indispensable trace element, iron is essential for many biological processes. Increasing evidence has shown that virus infection can perturb iron metabolism and play a role in the occurrence and development of viral infection-related diseases. Ferritin plays a crucial role in maintaining the body's iron homoeostasis. It is an important protein to stabilise the iron balance in cells. Ferritin is a 24-mer hollow iron storage protein composed of two subunits: ferritin heavy chain and ferritin light chain. It was reported that ferritin is not only an intra-cellular iron storage protein, but also a pathogenic mediator that enhances the inflammatory process and stimulates the further inflammatory pathway, which is a key member of the vicious pathogenic cycle to perpetuate. Ferritin exerts immuno-suppressive and pro-inflammatory functions during viral infection. In this review, we describe in detail the basic information of ferritin in the first section, including its structural features, the regulation of ferritin. In the second part, we focus on the role of ferritin in viral infection-related diseases and the molecular mechanisms by which viral infection regulates ferritin. The last section briefly outlines the potential of ferritin in antiviral therapy. Given the importance of iron and viral infection, understanding the role of ferritin during viral infection helps us understand the relationship between iron metabolic dysfunction and viral infection, which provides a new direction for the development of antiviral therapeutic drugs.

铁蛋白:在病毒感染中的意义。
作为一种不可或缺的微量元素,铁对许多生物过程都至关重要。越来越多的证据表明,病毒感染会扰乱铁代谢,并在病毒感染相关疾病的发生和发展中发挥作用。铁蛋白在维持人体铁平衡方面发挥着至关重要的作用。它是稳定细胞中铁平衡的重要蛋白质。铁蛋白是一种 24 聚体的中空铁储存蛋白,由两个亚基组成:铁蛋白重链和铁蛋白轻链。据报道,铁蛋白不仅是一种细胞内铁贮存蛋白,还是一种致病介质,能增强炎症过程,刺激炎症通路的进一步发展,是恶性致病循环得以延续的关键成员。铁蛋白在病毒感染过程中发挥免疫抑制和促炎功能。在这篇综述中,我们将在第一部分详细介绍铁蛋白的基本信息,包括其结构特征、铁蛋白的调控。第二部分,我们将重点讨论铁蛋白在病毒感染相关疾病中的作用以及病毒感染调控铁蛋白的分子机制。最后一部分简要概述了铁蛋白在抗病毒治疗中的潜力。鉴于铁与病毒感染的重要性,了解铁蛋白在病毒感染过程中的作用有助于我们理解铁代谢功能障碍与病毒感染之间的关系,这为开发抗病毒治疗药物提供了新的方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Reviews in Medical Virology
Reviews in Medical Virology 医学-病毒学
CiteScore
21.40
自引率
0.90%
发文量
88
期刊介绍: Reviews in Medical Virology aims to provide articles reviewing conceptual or technological advances in diverse areas of virology. The journal covers topics such as molecular biology, cell biology, replication, pathogenesis, immunology, immunization, epidemiology, diagnosis, treatment of viruses of medical importance, and COVID-19 research. The journal has an Impact Factor of 6.989 for the year 2020. The readership of the journal includes clinicians, virologists, medical microbiologists, molecular biologists, infectious disease specialists, and immunologists. Reviews in Medical Virology is indexed and abstracted in databases such as CABI, Abstracts in Anthropology, ProQuest, Embase, MEDLINE/PubMed, ProQuest Central K-494, SCOPUS, and Web of Science et,al.
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