Development and applications of peri-implantitis mouse models.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2024-09-01 Epub Date: 2024-03-19 DOI:10.1111/odi.14929

Jianwei Zhang, Zian Tong, Long Chen, Yinjie Qian, Yifan Lu, Qianming Chen, Misi Si

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引用次数: 0

Abstract

Objective: Peri-implantitis is one of the most common complications of implants. However, its pathogenesis has not been clarified. In recent years, mouse models are gradually being used in the study of peri-implantitis. This review aims to summarize the methods used to induce peri-implantitis in mice and their current applications.

Method: Articles of peri-implantitis mouse models were collected. We analyzed the various methods of inducing peri-implantitis and their application in different areas.

Results: Most researchers have induced peri-implantitis by silk ligatures. Some others have induced peri-implantitis by Pg gavage and LPS injection. Current applications of peri-implantitis mouse models are in the following areas: investigation of pathogenesis and exploration of new interventions, comparison of peri-implantitis with periodontitis, the interaction between systemic diseases and peri-implantitis, etc. CONCLUSION: Silk ligature for 2-4 weeks, Pg gavage for 6 weeks, and LPS injection for 6 weeks all successfully induced peri-implantitis in mice. Mice have the advantages of mature gene editing technology, low cost, and short time to induce peri-implantitis. It has applications in the study of pathogenesis, non-surgical treatments, and interactions with other diseases. However, compared with large animals, mice also have a number of disadvantages that limit their application.

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种植体周围炎小鼠模型的开发与应用。

目的：种植体周围炎是种植体最常见的并发症之一。然而，其发病机制尚未明确。近年来，小鼠模型逐渐被用于研究种植体周围炎。本综述旨在总结诱导小鼠种植体周围炎的方法及其目前的应用情况：方法：收集有关种植周炎小鼠模型的文章。我们分析了诱导种植体周围炎的各种方法及其在不同领域的应用：结果：大多数研究人员通过丝线结扎诱导种植体周围炎。结果：大多数研究人员采用丝线结扎法诱导种植体周围炎，还有一些研究人员采用 Pg 灌胃法和 LPS 注射法诱导种植体周围炎。目前种植体周围炎小鼠模型的应用领域包括：研究发病机制和探索新的干预措施、种植体周围炎与牙周炎的比较、全身性疾病与种植体周围炎之间的相互作用等。结论：丝线结扎 2-4 周、Pg 灌胃 6 周和 LPS 注射 6 周均能成功诱导小鼠发生种植体周围炎。小鼠诱导种植体周围炎具有基因编辑技术成熟、成本低、时间短等优点。它在研究发病机制、非手术治疗以及与其他疾病的相互作用等方面都有应用。然而，与大型动物相比，小鼠也存在一些缺点，限制了其应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.

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