COVID-19 Vaccine-Related Movement Disorders: A Systematic Review.

IF 2.5 4区医学 Q2 CLINICAL NEUROLOGY

Journal of Movement Disorders Pub Date : 2024-07-01 Epub Date: 2024-03-19 DOI:10.14802/jmd.24001

Grace Elysse D Angeles, Lowrence Precious C Dichoso, Roland Dominic G Jamora

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Abstract

Objective: Since the release of vaccines against coronavirus disease 2019 (COVID-19), there have been reports of vaccine-related neurologic complications. This study aimed to perform a descriptive systematic review of movement disorders associated with COVID-19 vaccines.

Methods: We described the demographics, clinical presentation, management, outcomes, and proposed pathomechanism of the patients. A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A standardized tool was used to assess the quality of the cases.

Results: We identified 8 articles that met our inclusion criteria; these articles included 10 patients who developed movement disorders after vaccination. The majority were males (n = 8), with a median age of 64.5 years. The most common movement disorder was hemichorea. The rest presented with generalized chorea with myoclonus, cervical dystonia, and akathisia. Most patients respond to immunotherapy. The standardized tool used showed that most studies had a low risk of bias.

Conclusion: The reported incidence of vaccine-related movement disorders was low based on available published cases.

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与 COVID-19 疫苗相关的运动障碍：系统综述。

目的：自 COVID-19 疫苗上市以来，已有疫苗相关神经系统并发症的报道。本研究旨在对与 COVID-19 疫苗相关的运动障碍进行描述性系统回顾：方法：我们描述了人口统计学、临床表现、管理、结果和建议的病理机制。根据 PRISMA 指南进行了系统回顾。采用标准化工具评估病例质量：我们共发现了 8 篇符合纳入标准的文章，其中包括 10 名接种疫苗后出现运动障碍的患者。大多数患者为男性（n = 8），中位年龄为 64.5 岁。最常见的运动障碍是半身不遂。其余病例表现为伴有肌阵挛的全身舞蹈症、颈肌张力障碍和运动障碍。大多数病例对免疫疗法有反应。使用的标准化工具显示，大多数研究的偏倚风险较低：结论：根据已发现的公开病例，疫苗相关运动障碍的发病率较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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