Associations of Early Gut Microbiome and Metabolome with Growth and Body Composition of Preterm Infants Within the First 6 Months.

IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY
Breastfeeding Medicine Pub Date : 2024-06-01 Epub Date: 2024-03-19 DOI:10.1089/bfm.2023.0258
Xinhui Guo, Junyan Han, Luyang Hong, Yihuang Huang, Shujuan Li, Lan Zhang, Weili Yan, Ping Dong, Yi Yang, Yun Cao
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引用次数: 0

Abstract

Objectives: This study aimed to explore the associations of growth and body composition with gut microbiome and metabolome in preterm infants. Materials and Methods: A prospective cohort study including 73 human milk-fed very preterm infants was conducted. During hospitalization, fecal samples were collected to detect microbes and metabolites using 16S rRNA gene sequencing and liquid chromatography-mass spectrometry. Growth and body composition indices were measured at term equivalent age (TEA) and 6 months of corrected age (CA). Associations of the fecal microbiome and metabolome profiles with growth and body composition indices, as well as their changes, were analyzed. Results: A higher abundance of Streptococcus was associated with a lower fat-free mass (FFM) z-score at 6 months of CA (p = 0.002) and a smaller increase in FFM z-score from TEA to 6 months of CA (p = 0.018). Higher levels of 3'-sialyllactose and 6'-sialyllactose (6'-SL) in feces were correlated with a lower z-score of percentage body fat (PBF) (p = 0.018 and 0.020, respectively) and a lower z-score of fat mass (p = 0.044 and 0.043, respectively) at 6 months of CA. A higher level of 6'-SL in feces was correlated with a greater increase in FFM z-score from TEA to 6 months of CA (p = 0.021). Conclusions: This study sheds light on the role of specific microbial-host interactions in metabolic changes in preterm infants, indicating the potential role of sialylated human milk oligosaccharides in optimizing body composition.

6个月内早产儿早期肠道微生物组和代谢组与生长和身体成分的关系
研究目的本研究旨在探讨早产儿的生长和身体组成与肠道微生物组和代谢组的关系。材料与方法:研究人员对 73 名母乳喂养的极早产儿进行了前瞻性队列研究。在住院期间收集粪便样本,使用 16S rRNA 基因测序和液相色谱-质谱法检测微生物和代谢物。在足月等效年龄(TEA)和 6 个月矫正年龄(CA)时测量了生长和身体成分指数。分析了粪便微生物组和代谢组特征与生长和身体成分指数的关系及其变化。结果发现链球菌含量较高与6个月大时较低的去脂体重(FFM)z-score相关(p = 0.002),而从TEA到6个月大时FFM z-score的增幅较小(p = 0.018)。在 CA 6 个月时,粪便中较高水平的 3'-sialyllactose 和 6'-sialyllactose (6'-SL) 与较低的体脂百分比 (PBF) z 值(p = 0.018 和 0.020,分别为 0.018 和 0.020)和较低的脂肪量 z 值(p = 0.044 和 0.043,分别为 0.044 和 0.043)相关。粪便中 6'-SL 的水平越高,则从 TEA 到 CA 6 个月期间脂肪量 z 值的增加幅度越大(p = 0.021)。结论:这项研究揭示了特定微生物-宿主相互作用在早产儿新陈代谢变化中的作用,表明硅烷基化人乳低聚糖在优化身体组成中的潜在作用。
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来源期刊
Breastfeeding Medicine
Breastfeeding Medicine OBSTETRICS & GYNECOLOGY-PEDIATRICS
CiteScore
4.20
自引率
11.10%
发文量
130
审稿时长
6-12 weeks
期刊介绍: Breastfeeding Medicine provides unparalleled peer-reviewed research, protocols, and clinical applications to ensure optimal care for mother and infant. The Journal answers the growing demand for evidence-based research and explores the immediate and long-term outcomes of breastfeeding, including its epidemiologic, physiologic, and psychological benefits. It is the exclusive source of the Academy of Breastfeeding Medicine protocols. Breastfeeding Medicine coverage includes: Breastfeeding recommendations and protocols Health consequences of artificial feeding Physiology of lactation and biochemistry of breast milk Optimal nutrition for the breastfeeding mother Breastfeeding indications and contraindications Managing breastfeeding discomfort, pain, and other complications Breastfeeding the premature or sick infant Breastfeeding in the chronically ill mother Management of the breastfeeding mother on medication Infectious disease transmission through breast milk and breastfeeding The collection and storage of human milk and human milk banking Measuring the impact of being a “baby-friendly” hospital Cultural competence and cultural sensitivity International public health issues including social and economic issues.
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