Association of Human Milk Fatty Acid Composition with Maternal Cardiometabolic Diseases: An Exploratory Prospective Cohort Study.

IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY
Breastfeeding Medicine Pub Date : 2024-05-01 Epub Date: 2024-03-19 DOI:10.1089/bfm.2024.0019
Natalie V Scime, Sarah Turner, Kozeta Miliku, Elinor Simons, Theo J Moraes, Catherine J Field, Stuart E Turvey, Padmaja Subbarao, Piushkumar J Mandhane, Meghan B Azad
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引用次数: 0

Abstract

Background: Human milk fatty acids derive from maternal diet, body stores, and mammary synthesis and may reflect women's underlying cardiometabolic health. We explored whether human milk fatty acid composition was associated with maternal cardiometabolic disease (CMD) during pregnancy and up to 5 years postpartum. Materials and Methods: We analyzed data from the prospective CHILD Cohort Study on 1,018 women with no preexisting CMD who provided breast milk samples at 3-4 months postpartum. Milk fatty acid composition was measured using gas-liquid chromatography. Maternal CMD (diabetes or hypertension) was classified using questionnaires and birth records as no CMD (reference outcome group; 81.1%), perinatal CMD (developed and resolved during the perinatal period; 14.9%), persistent CMD (developed during, and persisted beyond, the perinatal period; 2.9%), and incident CMD (developed after the perinatal period; 1.1%). Multinomial logistic regression was used to model associations between milk fatty acid composition (individual, summary, ratios, and patterns identified using principal component analysis) and maternal CMD, adjusting for pre-pregnancy anthropometry and race/ethnicity. Results: Medium-chain saturated fatty acids (MC-SFA), lauric (C12:0; odds ratio [OR] = 0.73, 95% confidence interval [CI] = 0.60-0.89) and myristic acid (C14:0; OR = 0.80, 95% CI = 0.66-0.97), and the high MC-SFA principal component pattern (OR = 0.86, 95% CI = 0.76-0.96) were inversely associated with perinatal CMD. Long-chain polyunsaturated fatty acids adrenic acid (C22:4n-6) was positively associated with perinatal (OR = 1.21, 95% CI = 1.01-1.44) and persistent CMD (OR = 1.56, 95% CI = 1.08-2.25). The arachidonic (C20:4n-6)-to-docosahexaenoic acid (C22:6n-3) ratio was inversely associated with incident CMD (OR = 0.52, 95% CI = 0.28-0.96). Conclusions: These exploratory findings highlight a potential novel utility of breast milk for understanding women's cardiometabolic health.

母乳脂肪酸组成与孕产妇心脏代谢疾病的关系:一项探索性前瞻性队列研究
背景:母乳脂肪酸来源于母体饮食、体内储存和乳腺合成,可能反映了妇女潜在的心脏代谢健康状况。我们探讨了母乳脂肪酸组成是否与孕期和产后 5 年内的产妇心脏代谢疾病(CMD)有关。材料和方法:我们分析了前瞻性 CHILD 队列研究中 1,018 名未患 CMD 的妇女的数据,这些妇女在产后 3-4 个月提供了母乳样本。采用气液色谱法测量了母乳中的脂肪酸组成。通过问卷调查和出生记录,将母体CMD(糖尿病或高血压)分为无CMD(参考结果组;81.1%)、围产期CMD(围产期发病并缓解;14.9%)、持续性CMD(围产期发病并持续到围产期后;2.9%)和偶发性CMD(围产期后发病;1.1%)。在调整孕前人体测量和种族/人种的基础上,采用多项式逻辑回归法建立牛奶脂肪酸组成(个体、总和、比率和使用主成分分析确定的模式)与孕产妇慢性阻塞性肺病之间的关系模型。研究结果中链饱和脂肪酸(MC-SFA)、月桂酸(C12:0;比值比 [OR] = 0.73,95% 置信区间 [CI] = 0.60-0.89)和肉豆蔻酸(C14:0;比值比 = 0.80,95% 置信区间 = 0.66-0.97)以及高 MC-SFA 主成分模式(比值比 = 0.86,95% 置信区间 = 0.76-0.96)与围产期 CMD 呈反比。长链多不饱和脂肪酸肾上腺酸(C22:4n-6)与围产期(OR = 1.21,95% CI = 1.01-1.44)和持续性 CMD(OR = 1.56,95% CI = 1.08-2.25)呈正相关。花生四烯酸(C20:4n-6)与二十二碳六烯酸(C22:6n-3)的比值与CMD发病率成反比(OR = 0.52,95% CI = 0.28-0.96)。结论这些探索性发现凸显了母乳在了解女性心脏代谢健康方面的潜在新用途。
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来源期刊
Breastfeeding Medicine
Breastfeeding Medicine OBSTETRICS & GYNECOLOGY-PEDIATRICS
CiteScore
4.20
自引率
11.10%
发文量
130
审稿时长
6-12 weeks
期刊介绍: Breastfeeding Medicine provides unparalleled peer-reviewed research, protocols, and clinical applications to ensure optimal care for mother and infant. The Journal answers the growing demand for evidence-based research and explores the immediate and long-term outcomes of breastfeeding, including its epidemiologic, physiologic, and psychological benefits. It is the exclusive source of the Academy of Breastfeeding Medicine protocols. Breastfeeding Medicine coverage includes: Breastfeeding recommendations and protocols Health consequences of artificial feeding Physiology of lactation and biochemistry of breast milk Optimal nutrition for the breastfeeding mother Breastfeeding indications and contraindications Managing breastfeeding discomfort, pain, and other complications Breastfeeding the premature or sick infant Breastfeeding in the chronically ill mother Management of the breastfeeding mother on medication Infectious disease transmission through breast milk and breastfeeding The collection and storage of human milk and human milk banking Measuring the impact of being a “baby-friendly” hospital Cultural competence and cultural sensitivity International public health issues including social and economic issues.
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