Revolutionizing cellular energy: The convergence of mitochondrial dynamics and delivery technologies

IF 3.9 3区生物学 Q2 CELL BIOLOGY

Mitochondrion Pub Date : 2024-03-17 DOI:10.1016/j.mito.2024.101873

Dilpreet Singh

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引用次数: 0

Abstract

The intersection of mitochondrial dynamics and delivery technologies heralds a paradigm shift in cellular biology and therapeutic intervention. Mitochondrial dynamics, encompassing fusion, fission, transport, and mitophagy, are critical for cellular energy production, signaling, and homeostasis. Dysregulation of these processes is implicated in a myriad of diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. Concurrently, advances in delivery technologies, such as nanocarriers, targeted delivery systems, and gene editing tools, offer unprecedented opportunities to manipulate mitochondrial function directly. This review synthesizes current knowledge on mitochondrial dynamics, examines recent breakthroughs in targeted delivery methods, and explores their potential convergence to modulate cellular energetics for therapeutic purposes. By integrating insights from biology, chemistry, and bioengineering, this review highlights the innovative approaches being developed to enhance mitochondrial function, underscoring the potential of this convergence to address complex diseases. This interdisciplinary perspective not only broadens our understanding of cellular processes but also paves the way for novel therapeutic strategies, marking a significant step forward in the quest for precision medicine and targeted interventions in mitochondrial-related diseases.

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细胞能量革命：线粒体动力学与传输技术的融合

线粒体动力学与传输技术的交叉预示着细胞生物学和治疗干预的范式转变。线粒体动力学包括融合、裂变、转运和有丝分裂，对细胞能量生产、信号传递和平衡至关重要。这些过程的失调与神经退行性疾病、心血管疾病和癌症等多种疾病有关。与此同时，纳米载体、靶向给药系统和基因编辑工具等给药技术的进步为直接操纵线粒体功能提供了前所未有的机会。这篇综述综述了线粒体动力学的现有知识，研究了靶向给药方法的最新突破，并探讨了它们在调节细胞能量以达到治疗目的方面的潜在融合。通过整合生物学、化学和生物工程的见解，这篇综述重点介绍了正在开发的增强线粒体功能的创新方法，强调了这种融合在解决复杂疾病方面的潜力。这种跨学科的视角不仅拓宽了我们对细胞过程的理解，还为新型治疗策略铺平了道路，标志着我们在寻求精准医疗和线粒体相关疾病的靶向干预方面迈出了重要一步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mitochondrion 生物-细胞生物学

CiteScore

9.40

自引率

4.50%

发文量

审稿时长

13.6 weeks

期刊介绍： Mitochondrion is a definitive, high profile, peer-reviewed international research journal. The scope of Mitochondrion is broad, reporting on basic science of mitochondria from all organisms and from basic research to pathology and clinical aspects of mitochondrial diseases. The journal welcomes original contributions from investigators working in diverse sub-disciplines such as evolution, biophysics, biochemistry, molecular and cell biology, genetics, pharmacology, toxicology, forensic science, programmed cell death, aging, cancer and clinical features of mitochondrial diseases.