The Lacunae identified in processing, analyzing and finding means of catalyst free Oxone mediated through C-3 oxidation of N-alkyl quinoxalin-2(1h)-one

IF 1.8 3区 化学 Q3 CHEMISTRY, ORGANIC
Vikas S. Patil , Gayathri Chunduri , Balaram Kiran Avasarala , Gangaiah L , Pasham Yoganand , Kola Srinivas , Murali Koparala , Nagaraju Devunuri
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引用次数: 0

Abstract

A catalyst free oxone mediated synthesizing N-alkyl 1, 4-dihydroquinoxaline-2,3-dione has been developed by oxidation of the N-alkyl quinoxalin-2(1H)-one. The developed method is a novel, safest, cost-effective, industrially viable method and applicable for N-substituted and without substitution of 1,4-dihydroquinoxaline-2,3-dione. Consequently, the process is applicable to a broad spectrum of functionality. The reaction can be performed in all organic solvents without any further heating with an extended time and without generating side products. This novel synthetic methodology using Oxone is believed to be the shortest and most efficient to prepare various key intermediates which can be used for further derivatization to make the different biologically active molecules, the key feature of this methodology is not solvent specific, all organic solvents giving the optimum purity and quality using the same reaction condition.

在处理、分析和寻找通过 C-3 氧化 N-烷基喹喔啉-2(1h)-酮介导的无催化剂 Oxone 的方法过程中发现的缺陷
通过氧化 N-烷基喹喔啉-2(1H)-酮,开发了一种无催化剂氧化酮介导合成 N-烷基 1,4-二氢喹喔啉-2,3-二酮的方法。所开发的方法是一种新颖、安全、简便的合成方法。
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来源期刊
Synthetic Communications
Synthetic Communications 化学-有机化学
CiteScore
4.40
自引率
4.80%
发文量
156
审稿时长
4.3 months
期刊介绍: Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.
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