{"title":"Cell-free systems for a multi-pronged approach to next-generation therapeutics and diagnostics","authors":"","doi":"10.1007/s12257-024-00058-w","DOIUrl":null,"url":null,"abstract":"<h3>Abstract</h3> <p>Effective diagnostics and therapeutics are foundational to modern medical technology. As the drug modality transitions from traditional small-molecule drugs to more intricate protein and nucleic acid-based therapies, there is mounting momentum towards personalized therapeutic approaches. These evolving paradigms challenge conventional biomanufacturing practices, highlighting the need for agile and patient-centric methodologies. Cell-free protein synthesis (CFPS), which facilitates the direct and programmable production of recombinant proteins, emerges as a compelling alternative. It offers rapid, adaptable, and customized protein production capabilities. Furthermore, by leveraging the core molecular mechanisms of gene expression, CFPS is gaining traction in the diagnostics realm, addressing the growing need for sophisticated diagnostic tools. In this review, we survey recent advancements and discuss how CFPS is poised to markedly reshape therapeutic production and diagnostic methods in the foreseeable future.</p>","PeriodicalId":8936,"journal":{"name":"Biotechnology and Bioprocess Engineering","volume":"52 1","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2024-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biotechnology and Bioprocess Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s12257-024-00058-w","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Effective diagnostics and therapeutics are foundational to modern medical technology. As the drug modality transitions from traditional small-molecule drugs to more intricate protein and nucleic acid-based therapies, there is mounting momentum towards personalized therapeutic approaches. These evolving paradigms challenge conventional biomanufacturing practices, highlighting the need for agile and patient-centric methodologies. Cell-free protein synthesis (CFPS), which facilitates the direct and programmable production of recombinant proteins, emerges as a compelling alternative. It offers rapid, adaptable, and customized protein production capabilities. Furthermore, by leveraging the core molecular mechanisms of gene expression, CFPS is gaining traction in the diagnostics realm, addressing the growing need for sophisticated diagnostic tools. In this review, we survey recent advancements and discuss how CFPS is poised to markedly reshape therapeutic production and diagnostic methods in the foreseeable future.
期刊介绍：
Biotechnology and Bioprocess Engineering is an international bimonthly journal published by the Korean Society for Biotechnology and Bioengineering. BBE is devoted to the advancement in science and technology in the wide area of biotechnology, bioengineering, and (bio)medical engineering. This includes but is not limited to applied molecular and cell biology, engineered biocatalysis and biotransformation, metabolic engineering and systems biology, bioseparation and bioprocess engineering, cell culture technology, environmental and food biotechnology, pharmaceutics and biopharmaceutics, biomaterials engineering, nanobiotechnology, and biosensor and bioelectronics.
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