Crosstalk between TPC2 and IP₃R regulates Ca²⁺ signals.

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2024-05-01 Epub Date: 2024-03-16 DOI:10.1016/j.tcb.2024.03.001

Christina Humer, Rainer Schindl, Matthias Sallinger

引用次数: 0

Abstract

Calcium (Ca²⁺) plays a pivotal role in cellular signal transmission by triggering downstream signaling in response to an increase in the cytosolic Ca²⁺ concentration. Intracellular organelles serve as Ca²⁺ stores that induce differently shaped Ca²⁺ signals. We discuss a study by Yuan et al. that investigated the interplay between the lysosomal two-pore channel 2 (TPC2) and endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptors (IP₃Rs).

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TPC2 和 IP3R 之间的相互影响调节着 Ca2+ 信号。

钙（Ca2+）在细胞信号传递过程中起着关键作用，它能根据细胞膜 Ca2+ 浓度的增加触发下游信号传递。细胞内的细胞器可作为 Ca2+ 储存库，诱导不同形状的 Ca2+ 信号。我们讨论了 Yuan 等人的一项研究，该研究调查了溶酶体双孔通道 2（TPC2）与内质网（ER）定位的 1,4,5-三磷酸肌醇受体（IP3Rs）之间的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.

Crosstalk between TPC2 and IP3R regulates Ca2+ signals.

Abstract

Crosstalk between TPC2 and IP₃R regulates Ca²⁺ signals.