Cryogel wound dressings based on natural polysaccharides perfectly adhere to irregular wounds for rapid haemostasis and easy disassembly.

IF 3.8 3区 医学 Q2 CELL BIOLOGY
Wound Repair and Regeneration Pub Date : 2024-07-01 Epub Date: 2024-03-17 DOI:10.1111/wrr.13173
Changchun Liu, Jiaqi Liu, Minmin Wu, Haifeng Ni, Jie Feng, Liping Zhao, Jing Zhang
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Abstract

Skin injuries can have unexpected surfaces, leading to uneven wound surfaces and inadequate dressing contact with these irregular surfaces. This can decrease the dressing's haemostatic action and increase the healing period. This study recommends the use of sticky and flexible cryogel coverings to promote faster haemostasis and efficiently handle uneven skin wounds. Alginate cryogels have a fast haemostatic effect and shape flexibility due to their macroporous structure. The material demonstrates potent antibacterial characteristics and enhances skin adherence by adding grafted chitosan with gallic acid. In irregular defect wound models, cryogels can cling closely to uneven damage surfaces due to their amorphous nature. Furthermore, their macroporous structure allows for quick haemostasis by quickly absorbing blood and wound exudate. After giving the dressing a thorough rinse, its adhesive strength reduces and it is simple to remove without causing any damage to the wound. Cryogel demonstrated faster haemostasis than gauze in a wound model on a rat tail, indicating that it has considerable potential for use as a wound dressing in the biomedical area.

基于天然多糖的低温凝胶伤口敷料可完美粘附在不规则的伤口上,实现快速止血和轻松拆卸。
皮肤损伤可能会有意想不到的表面,导致伤口表面不平整,敷料与这些不规则表面的接触不充分。这会降低敷料的止血作用,延长愈合时间。本研究建议使用粘性和柔性低温凝胶覆盖物,以加快止血速度并有效处理不平整的皮肤伤口。藻酸盐低温凝胶具有快速止血效果,且因其大孔结构而具有形状灵活性。这种材料具有强大的抗菌特性,并通过添加接枝壳聚糖和没食子酸增强了皮肤粘附性。在不规则缺损伤口模型中,低温凝胶因其无定形性质可紧贴不平整的损伤表面。此外,其大孔结构还能快速吸收血液和伤口渗出物,从而实现快速止血。对敷料进行彻底冲洗后,其粘附强度会降低,而且很容易去除,不会对伤口造成任何损伤。在大鼠尾部的伤口模型中,冷冻凝胶比纱布止血更快,这表明它在生物医学领域作为伤口敷料具有相当大的应用潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Wound Repair and Regeneration
Wound Repair and Regeneration 医学-皮肤病学
CiteScore
5.90
自引率
3.40%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Wound Repair and Regeneration provides extensive international coverage of cellular and molecular biology, connective tissue, and biological mediator studies in the field of tissue repair and regeneration and serves a diverse audience of surgeons, plastic surgeons, dermatologists, biochemists, cell biologists, and others. Wound Repair and Regeneration is the official journal of The Wound Healing Society, The European Tissue Repair Society, The Japanese Society for Wound Healing, and The Australian Wound Management Association.
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