Thiamine Deficiency Neuropathy in a Patient with Malnutrition due to Melancholic Depression.

Q4 Medicine
Case Reports in Psychiatry Pub Date : 2024-03-08 eCollection Date: 2024-01-01 DOI:10.1155/2024/1797983
Rihene Melki, Rim Ben Soussia, Houcem Elomma Mrabet, Walid Bouali, Lazhar Zarrouk
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Abstract

Introduction: Melancholic depression is a daily clinical reality in psychiatry. It is a therapeutic emergency that can jeopardize life if not promptly and adequately treated. Apart from its high suicidal risk, complications related to the under-nourishment state are to be feared. Case Presentation. A 36-year-old woman was admitted with depressive symptoms, significant weight loss, and total functional impotence. Laboratory investigations revealed severe thiamine (vitamin B1) deficiency. An electromyography confirmed a sensory axonal neuropathy involving all four extremities suggesting a deficiency origin. Discussion. Vitamin and mineral deficiencies have been described in patients with malnutrition resulting from psychiatric illness (anorexia nervosa, eating disorders, severe depression, etc.). Thiamine is an essential cofactor in several biochemical pathways. Its deficiency can lead to neuropsychiatric morbidity.

Conclusion: In our case, the rapid weight loss facilitated a cascade of complications related to nutritional deficiencies. Based on our clinical observations and the literature, thiamine deficiency should be considered in the presence of malnutrition and vulnerability, both on an organic and psychiatric level.

一名因忧郁抑郁症而营养不良的患者的硫胺素缺乏性神经病。
简介忧郁抑郁症是精神病学的日常临床现实。如果得不到及时和适当的治疗,它可能会危及生命。除了极高的自杀风险外,与营养不良状态相关的并发症也令人担忧。病例介绍。一名 36 岁的女性因抑郁症状、体重明显减轻和完全功能性阳痿入院。实验室检查发现其严重缺乏硫胺素(维生素 B1)。肌电图检查证实,她的四肢均有感觉性轴索神经病变,这表明她缺乏硫胺素。讨论。精神疾病(神经性厌食症、进食障碍、严重抑郁症等)导致营养不良的患者中也存在维生素和矿物质缺乏症。硫胺素是多种生化途径中不可或缺的辅助因子。缺乏硫胺素会导致神经精神疾病:在我们的病例中,体重的急剧下降引发了一系列与营养缺乏有关的并发症。根据我们的临床观察和文献资料,在出现营养不良和易患器质性和精神性疾病时,应考虑硫胺素缺乏症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Case Reports in Psychiatry
Case Reports in Psychiatry Medicine-Psychiatry and Mental Health
CiteScore
1.00
自引率
0.00%
发文量
49
审稿时长
12 weeks
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