Plasma membrane damage is a new trigger of cellular senescence.

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2024-06-01 Epub Date: 2024-03-15 DOI:10.1016/j.tcb.2024.03.002

Nadine Martin, Céline Margand, David Bernard

引用次数: 0

Abstract

By blocking proliferation and inducing a secretory phenotype, cellular senescence has beneficial and deleterious effects, the latter being linked to aging. Suda et al. recently reported that plasma membrane (PM) damage (PMD) triggers senescence, suggesting that PMD inducers promote senescence and that the PMD repair machinery can regulate it.

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质膜损伤是细胞衰老的新诱因。

通过阻止增殖和诱导分泌表型，细胞衰老具有有益和有害的影响，后者与衰老有关。Suda 等人最近报告说，质膜损伤（PMD）会引发衰老，这表明质膜损伤诱导剂会促进衰老，而质膜损伤修复机制可以调节衰老。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.