Structural cell heterogeneity underlies the differential contribution of IL-17A, IL-17F and IL-23 to joint versus skin chronic inflammation

IF 9.2 1区 医学 Q1 IMMUNOLOGY
Marie Robert, Pierre Miossec
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引用次数: 0

Abstract

The current therapeutic strategy used in immune-mediated inflammatory diseases (IMIDs) primarily targets immune cells or associated-pathways. However, recent evidence suggests that the microenvironment modulates immune cell development and responses. During inflammation, structural cells acquire a pathogenetic phenotype and the interactions with immune cells are often greatly modified. Understanding the importance of these tissue-specific interactions may allow to explain why some biologics are effective in some IMIDs but not in others. The differential effects of interleukin (IL)-17 A, IL-17F and IL-23 in joint versus skin inflammation depends on structural cell heterogeneity. In addition, the sometimes opposite effects of immune/structural cell interactions on the production of these cytokines illustrate the importance of these cells in chronic inflammation, using the examples of rheumatoid arthritis, psoriasis and spondyloarthritis. This review describes these concepts, shows their interests through clinical observations, and finally discusses strategies to optimize therapeutic strategies.

IL-17A、IL-17F 和 IL-23 对关节和皮肤慢性炎症的不同贡献是结构细胞异质性的基础。
目前用于免疫介导的炎症性疾病(IMIDs)的治疗策略主要针对免疫细胞或相关途径。然而,最近的证据表明,微环境会调节免疫细胞的发育和反应。在炎症过程中,结构细胞会获得致病表型,与免疫细胞的相互作用通常会发生很大变化。了解了这些组织特异性相互作用的重要性,就可以解释为什么一些生物制剂对某些 IMIDs 有效,而对另一些则无效。白细胞介素(IL)-17 A、IL-17F 和 IL-23 在关节炎症和皮肤炎症中的不同作用取决于结构细胞的异质性。此外,以类风湿性关节炎、银屑病和脊柱关节炎为例,免疫/结构细胞相互作用对这些细胞因子的产生有时会产生相反的影响,这说明了这些细胞在慢性炎症中的重要性。这篇综述描述了这些概念,通过临床观察说明了它们的重要性,最后讨论了优化治疗策略的策略。
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来源期刊
Autoimmunity reviews
Autoimmunity reviews 医学-免疫学
CiteScore
24.70
自引率
4.40%
发文量
164
审稿时长
21 days
期刊介绍: Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.
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