A metabolic pacer ensures smooth running of the lymphocyte activation race

IF 17.6 1区医学 Q1 IMMUNOLOGY

Science Immunology Pub Date : 2024-03-15 DOI:https://www.science.org/doi/10.1126/sciimmunol.adn4958

Veera Panova, Arianne C. Richard

引用次数: 0

Abstract

Upon lymphocyte stimulation, accumulation of intracellular NAD(H) reflects the strength of antigen receptor signals and controls the rate of cell cycle entry and proliferation (see related Research Article by Turner et al.).

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新陈代谢标兵确保淋巴细胞活化竞赛顺利进行

淋巴细胞受到刺激后，细胞内 NAD(H) 的积累反映了抗原受体信号的强度，并控制着细胞周期的进入和增殖速度（参见 Turner 等人的相关研究文章）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Immunology Immunology and Microbiology-Immunology

CiteScore

32.90

自引率

2.00%

发文量

183

期刊介绍： Science Immunology is a peer-reviewed journal that publishes original research articles in the field of immunology. The journal encourages the submission of research findings from all areas of immunology, including studies on innate and adaptive immunity, immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology. Additionally, the journal covers research on immune contributions to health and disease, such as host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency. Science Immunology maintains the same high-quality standard as other journals in the Science family and aims to facilitate understanding of the immune system by showcasing innovative advances in immunology research from all organisms and model systems, including humans.

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