Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments.

Cell metabolism Pub Date : 2024-06-04 Epub Date: 2024-03-14 DOI:10.1016/j.cmet.2024.02.014
Ever Espino-Gonzalez, Emilie Dalbram, Rémi Mounier, Julien Gondin, Jean Farup, Niels Jessen, Jonas T Treebak
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Abstract

Diabetes represents a major public health concern with a considerable impact on human life and healthcare expenditures. It is now well established that diabetes is characterized by a severe skeletal muscle pathology that limits functional capacity and quality of life. Increasing evidence indicates that diabetes is also one of the most prevalent disorders characterized by impaired skeletal muscle regeneration, yet underlying mechanisms and therapeutic treatments remain poorly established. In this review, we describe the cellular and molecular alterations currently known to occur during skeletal muscle regeneration in people with diabetes and animal models of diabetes, including its associated comorbidities, e.g., obesity, hyperinsulinemia, and insulin resistance. We describe the role of myogenic and non-myogenic cell types on muscle regeneration in conditions with or without diabetes. Therapies for skeletal muscle regeneration and gaps in our knowledge are also discussed, while proposing future directions for the field.

糖尿病患者骨骼肌再生能力受损:从细胞和分子机制到新型疗法。
糖尿病是一个重大的公共卫生问题,对人的生命和医疗开支都有相当大的影响。目前已经明确的是,糖尿病以严重的骨骼肌病变为特征,限制了患者的功能能力和生活质量。越来越多的证据表明,糖尿病也是以骨骼肌再生受损为特征的最常见疾病之一,但其潜在机制和治疗方法仍未得到充分确定。在这篇综述中,我们描述了目前已知的糖尿病患者和糖尿病动物模型在骨骼肌再生过程中发生的细胞和分子变化,包括与之相关的合并症,如肥胖、高胰岛素血症和胰岛素抵抗。我们描述了成肌细胞和非成肌细胞类型在糖尿病或非糖尿病情况下对肌肉再生的作用。我们还讨论了骨骼肌再生疗法和我们的知识空白,同时提出了该领域的未来发展方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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