The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria.

IF 4.2 3区 医学 Q2 ONCOLOGY
Clinical & Experimental Metastasis Pub Date : 2024-10-01 Epub Date: 2024-03-15 DOI:10.1007/s10585-024-10269-3
Sarah Libring, Emily D Berestesky, Cynthia A Reinhart-King
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引用次数: 0

Abstract

As a major energy source for cells, mitochondria are involved in cell growth and proliferation, as well as migration, cell fate decisions, and many other aspects of cellular function. Once thought to be irreparably defective, mitochondrial function in cancer cells has found renewed interest, from suggested potential clinical biomarkers to mitochondria-targeting therapies. Here, we will focus on the effect of mitochondria movement on breast cancer progression. Mitochondria move both within the cell, such as to localize to areas of high energetic need, and between cells, where cells within the stroma have been shown to donate their mitochondria to breast cancer cells via multiple methods including tunneling nanotubes. The donation of mitochondria has been seen to increase the aggressiveness and chemoresistance of breast cancer cells, which has increased recent efforts to uncover the mechanisms of mitochondrial transfer. As metabolism and energetics are gaining attention as clinical targets, a better understanding of mitochondrial function and implications in cancer are required for developing effective, targeted therapeutics for cancer patients.

Abstract Image

乳腺癌线粒体的移动:线粒体的内部移动和细胞间转移。
作为细胞的主要能量来源,线粒体参与了细胞的生长和增殖、迁移、细胞命运决定以及细胞功能的许多其他方面。癌细胞中的线粒体功能曾一度被认为存在无法弥补的缺陷,但现在人们对它重新产生了兴趣,从提出潜在的临床生物标志物到线粒体靶向疗法。在这里,我们将重点研究线粒体移动对乳腺癌进展的影响。线粒体既可在细胞内移动,如定位到高能量需求区域,也可在细胞间移动,基质中的细胞已被证明可通过隧道纳米管等多种方法向乳腺癌细胞捐赠线粒体。线粒体的捐献被认为会增加乳腺癌细胞的侵袭性和化疗抗性,这也增加了近期揭示线粒体转移机制的努力。随着新陈代谢和能量作为临床靶点越来越受到关注,需要更好地了解线粒体在癌症中的功能和影响,以便为癌症患者开发有效的靶向治疗药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.80
自引率
5.00%
发文量
55
审稿时长
12 months
期刊介绍: The Journal''s scope encompasses all aspects of metastasis research, whether laboratory-based, experimental or clinical and therapeutic. It covers such areas as molecular biology, pharmacology, tumor biology, and clinical cancer treatment (with all its subdivisions of surgery, chemotherapy and radio-therapy as well as pathology and epidemiology) insofar as these disciplines are concerned with the Journal''s core subject of metastasis formation, prevention and treatment.
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