Diagnostic insights from chemometric analysis of hemogram inflammatory indexes in male smokers with and without asthma or chronic obstructive pulmonary disease

IF 2.2 4区医学 Q3 HEMATOLOGY

International Journal of Laboratory Hematology Pub Date : 2024-03-15 DOI:10.1111/ijlh.14264

Brajesh Singh, Vijay Dutta, Smiti Singh, Priyanka Pundit

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Abstract

Background

Diagnosis of asthma and chronic obstructive pulmonary disease (COPD) becomes difficult in a primary healthcare center due to ambiguous interpretation of spirometry and lack of facility to access established biomarkers. While routine hematological indices are easily available and accessible. The study aimed to evaluate the role of different hemogram indexes in males in COPD, asthma, and healthy smokers.

Materials and Methods

Lung function tests and complete blood count (CBC) were done for 50 male subjects each from asthma, COPD, and healthy smokers. Multivariate analysis (MVA) was performed on blood indices data set. Receiver operating characteristic (ROC) curve was plotted to observe the performance of indexes. Pearson correlation was used to establish association between the lung function and blood indices.

Results

Most of the indices were elevated in COPD. Whereas, asthma patients showed a significant increase in eosinophil basophil ratio (EBR), lymphocyte-monocyte ratio (LMR), and mean platelet volume-platelet count ratio (MPR). Orthogonal (O)- Partial Least-Squares Discriminant Analysis (PLSDA) and variable importance in projection (VIP) score established EBR, neutrophil-lymphocyte ratio (NLR) and LMR, as discriminants for asthma. Whereas, Systemic Inflammatory Response Index (SIRI), NLR and EBR were the key variables for COPD. NLR (r = −0.73, p < 0.001) and SIRI (r = −0.71, p < 0.001) were found to be negatively correlated with forced expiratory volume in 1 s (FEV1) percentage of the predicted value (%pred) in asthma and COPD, respectively. EBR showed the sensitivity and specificity of 96% and 86% respectively in asthma. NLR was having sensitivity of 82% and 90% specificity in COPD.

Conclusion

Our study in males shows routine hematological indices as being cost-effective, feasible, and seem to have tremendous potential as screening markers among chronic respiratory diseases in a primary healthcare center.

查看原文本刊更多论文

从对患有和未患有哮喘或慢性阻塞性肺病的男性吸烟者血液图炎症指数的化学计量分析中获得诊断见解。

背景：在初级医疗保健中心，由于对肺活量测定的解释不明确以及缺乏获得既定生物标志物的设施，哮喘和慢性阻塞性肺病（COPD）的诊断变得十分困难。而常规血液学指标却很容易获得和使用。本研究旨在评估不同血液指标在男性慢性阻塞性肺病、哮喘和健康吸烟者中的作用：对哮喘、慢性阻塞性肺病和健康吸烟者各 50 名男性受试者进行了肺功能测试和全血细胞计数（CBC）。对血液指标数据集进行了多变量分析（MVA）。绘制了接收者操作特征（ROC）曲线，以观察指标的性能。使用皮尔逊相关性建立肺功能和血液指标之间的联系：结果：慢性阻塞性肺疾病患者的大部分指数都升高了。而哮喘患者的嗜酸性粒细胞-嗜碱性粒细胞比值（EBR）、淋巴细胞-单核细胞比值（LMR）和平均血小板体积-血小板计数比值（MPR）明显升高。正交（O）-部分最小二乘判别分析（PLSDA）和预测变量重要性（VIP）评分确定了嗜酸性粒细胞比率（EBR）、中性粒细胞-淋巴细胞比率（NLR）和淋巴细胞-淋巴细胞比率（LMR）是哮喘的判别因子。而全身炎症反应指数（SIRI）、NLR 和 EBR 是慢性阻塞性肺病的关键变量。NLR（r = -0.73，p 结论：SIRI、NLR 和 EBR 是哮喘的关键变量：我们在男性中进行的研究表明，常规血液学指标具有成本效益和可行性，而且作为初级医疗保健中心慢性呼吸系统疾病的筛查指标似乎具有巨大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Laboratory Hematology 医学-血液学

CiteScore

4.50

自引率

6.70%

发文量

211

审稿时长

6-12 weeks

期刊介绍： The International Journal of Laboratory Hematology provides a forum for the communication of new developments, research topics and the practice of laboratory haematology. The journal publishes invited reviews, full length original articles, and correspondence. The International Journal of Laboratory Hematology is the official journal of the International Society for Laboratory Hematology, which addresses the following sub-disciplines: cellular analysis, flow cytometry, haemostasis and thrombosis, molecular diagnostics, haematology informatics, haemoglobinopathies, point of care testing, standards and guidelines. The journal was launched in 2006 as the successor to Clinical and Laboratory Hematology, which was first published in 1979. An active and positive editorial policy ensures that work of a high scientific standard is reported, in order to bridge the gap between practical and academic aspects of laboratory haematology.