Physicochemical properties of 26 carbon nanotubes as predictors for pulmonary inflammation and acute phase response in mice following intratracheal lung exposure

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-03-13 DOI:10.1016/j.etap.2024.104413

Pernille Høgh Danielsen , Sarah Søs Poulsen , Kristina Bram Knudsen , Per Axel Clausen , Keld Alstrup Jensen , Håkan Wallin , Ulla Vogel

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引用次数: 0

Abstract

Carbon nanotubes (CNTs) vary in physicochemical properties which makes risk assessment challenging. Mice were pulmonary exposed to 26 well-characterized CNTs using the same experimental design and followed for one day, 28 days or 3 months. This resulted in a unique dataset, which was used to identify physicochemical predictors of pulmonary inflammation and systemic acute phase response. MWCNT diameter and SWCNT specific surface area were predictive of lower and higher neutrophil influx, respectively. Manganese and iron were shown to be predictive of higher neutrophil influx at day 1 post-exposure, whereas nickel content interestingly was predictive of lower neutrophil influx at all three time points and of lowered acute phase response at day 1 and 3 months post-exposure. It was not possible to separate effects of properties such as specific surface area and length in the multiple regression analyses due to co-variation.

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26 根碳纳米管的理化特性可预测小鼠气管内肺部暴露后的肺部炎症和急性期反应。

碳纳米管（CNTs）的理化性质各不相同，这给风险评估带来了挑战。采用相同的实验设计，将小鼠肺部暴露于 26 种特征明确的碳纳米管，并分别跟踪观察一天、28 天或 3 个月。这就产生了一个独特的数据集，用于确定肺部炎症和全身急性期反应的理化预测因子。MWCNT 直径和 SWCNT 比表面积分别可预测较低和较高的中性粒细胞流入。锰和铁可预测暴露后第 1 天更高的中性粒细胞流入，而有趣的是，镍含量可预测所有三个时间点更低的中性粒细胞流入，以及暴露后第 1 天和 3 个月更低的急性期反应。在多元回归分析中，由于存在共变因素，无法将比表面积和长度等属性的影响区分开来。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.