Static magnetic fields in regenerative medicine.

IF 6.6 3区 医学 Q1 ENGINEERING, BIOMEDICAL
APL Bioengineering Pub Date : 2024-03-13 eCollection Date: 2024-03-01 DOI:10.1063/5.0191803
Wenjing Xie, Chao Song, Ruowen Guo, Xin Zhang
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引用次数: 0

Abstract

All organisms on Earth live in the weak but ubiquitous geomagnetic field. Human beings are also exposed to magnetic fields generated by multiple sources, ranging from permanent magnets to magnetic resonance imaging (MRI) in hospitals. It has been shown that different magnetic fields can generate various effects on different tissues and cells. Among them, stem cells appear to be one of the most sensitive cell types to magnetic fields, which are the fundamental units of regenerative therapies. In this review, we focus on the bioeffects of static magnetic fields (SMFs), which are related to regenerative medicine. Most reports in the literature focus on the influence of SMF on bone regeneration, wound healing, and stem cell production. Multiple aspects of the cellular events, including gene expression, cell signaling pathways, reactive oxygen species, inflammation, and cytoskeleton, have been shown to be affected by SMFs. Although no consensus yet, current evidence indicates that moderate and high SMFs could serve as a promising physical tool to promote bone regeneration, wound healing, neural differentiation, and dental regeneration. All in vivo studies of SMFs on bone regeneration and wound healing have shown beneficial effects, which unravel the great potential of SMFs in these aspects. More mechanistic studies, magnetic field parameter optimization, and clinical investigations on human bodies will be imperative for the successful clinical applications of SMFs in regenerative medicine.

再生医学中的静态磁场。
地球上的所有生物都生活在微弱但无处不在的地磁场中。人类也暴露在从永久磁铁到医院磁共振成像(MRI)等多种来源产生的磁场中。研究表明,不同的磁场会对不同的组织和细胞产生不同的影响。其中,干细胞似乎是对磁场最敏感的细胞类型之一,是再生疗法的基本单位。在这篇综述中,我们重点讨论与再生医学有关的静态磁场(SMF)的生物效应。文献中的大多数报道都集中于静态磁场对骨再生、伤口愈合和干细胞生成的影响。细胞事件的多个方面,包括基因表达、细胞信号通路、活性氧、炎症和细胞骨架,已被证明受到 SMF 的影响。尽管尚未达成共识,但目前的证据表明,中度和高度 SMF 可作为一种有前途的物理工具,促进骨再生、伤口愈合、神经分化和牙齿再生。所有关于 SMF 对骨再生和伤口愈合的体内研究都显示出有益的效果,这揭示了 SMF 在这些方面的巨大潜力。更多的机理研究、磁场参数优化和人体临床研究将是 SMFs 在再生医学中成功临床应用的当务之急。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
APL Bioengineering
APL Bioengineering ENGINEERING, BIOMEDICAL-
CiteScore
9.30
自引率
6.70%
发文量
39
审稿时长
19 weeks
期刊介绍: APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems. APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioengineering publishes original research articles, reviews, and perspectives. Topical coverage includes: -Biofabrication and Bioprinting -Biomedical Materials, Sensors, and Imaging -Engineered Living Systems -Cell and Tissue Engineering -Regenerative Medicine -Molecular, Cell, and Tissue Biomechanics -Systems Biology and Computational Biology
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