Precise engineering of the biomolecular corona to accelerate the clinical translation of lipid nanoparticles.

IF 14.3 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Trends in biotechnology Pub Date : 2024-10-01 Epub Date: 2024-03-13 DOI:10.1016/j.tibtech.2024.02.012

Shahed Behzadi, Morteza Mahmoudi

引用次数: 0

Abstract

Understanding and meticulously engineering the biomolecular corona on the surface of lipid nanoparticles can accelerate their successful clinical applications beyond mRNA vaccines. We outline the major hurdles of clinical development faced by lipid nanoparticles and discuss how considering and modifying the biomolecular corona could mitigate these challenges.

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精确设计生物分子电晕，加速脂质纳米粒子的临床转化。

了解并精心设计脂质纳米粒子表面的生物分子电晕可以加速其在 mRNA 疫苗之外的成功临床应用。我们概述了脂质纳米粒子在临床开发中面临的主要障碍，并讨论了如何通过考虑和改造生物分子冠来缓解这些挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in biotechnology 工程技术-生物工程与应用微生物

CiteScore

28.60

自引率

1.20%

发文量

198

审稿时长

1 months

期刊介绍： Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems. The major themes that TIBTECH is interested in include: Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering) Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology) Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics) Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery) Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).