Carcinoma showing thymus-like elements (CASTLE) with amyloid deposition in the parotid gland.

IF 2.5 4区医学 Q2 PATHOLOGY

Pathology International Pub Date : 2024-04-01 Epub Date: 2024-03-15 DOI:10.1111/pin.13420

Mei Hamada, Yu Miyama, Satoko Matsumura, Yukako Shintani-Domoto, Makoto Urano, Masanori Yasuda

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引用次数: 0

Abstract

Carcinoma showing thymus-like elements (CASTLE) is a rare tumor that commonly occurs in the thyroid gland. Extrathyroidal CASTLE is rarer, and only 11 cases of CASTLE of major salivary glands have been reported to date. We report the first case of amyloid deposition in parotid CASTLE. A 63-year-old man presented with a slowly growing mass in the left parotid region. Computed tomography revealed an approximately 28 × 23 mm mass lesion in the left parotid gland, and squamous cell carcinoma was suspected on biopsy. The patient underwent a parotidectomy with neck dissection. Morphologically, the tumor cells were squamoid and formed nests with lymphoid infiltration. Immunohistochemically, the tumor cells exhibited immunoreactivity for CD5, CD117/c-kit and Bcl-2, p40, and CK5 but not for p16. We diagnosed the tumor as parotid CASTLE. Amyloid deposition was also observed in the primary tumor and metastatic lymph node lesions, which were immunoreactive for cytokeratin 5. Tumor cytokeratin-derived amyloid deposition may be one of characteristics of parotid CASTLE.

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腮腺中显示胸腺样成分（CASTLE）并伴有淀粉样沉积的癌。

显示胸腺样成分的癌症（CASTLE）是一种罕见的肿瘤，通常发生在甲状腺。甲状腺外CASTLE更为罕见，迄今为止仅有11例主要唾液腺CASTLE的报道。我们报告了首例腮腺CASTLE淀粉样蛋白沉积病例。一名 63 岁的男子因左侧腮腺区域缓慢生长的肿块而就诊。计算机断层扫描显示左侧腮腺有一个约 28 × 23 毫米的肿块病变，活检结果怀疑是鳞状细胞癌。患者接受了腮腺切除术和颈部切除术。从形态上看，肿瘤细胞呈鳞状，并形成淋巴浸润的巢状。免疫组化结果显示，肿瘤细胞对CD5、CD117/c-kit、Bcl-2、p40和CK5有免疫反应，但对p16无免疫反应。我们诊断该肿瘤为腮腺 CASTLE 癌。在原发肿瘤和转移淋巴结病灶中也观察到了淀粉样沉积，这些病灶对细胞角蛋白5有免疫反应。肿瘤细胞角蛋白衍生的淀粉样沉积可能是腮腺CASTLE的特征之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology International 医学-病理学

CiteScore

4.50

自引率

4.50%

发文量

102

审稿时长

12 months

期刊介绍： Pathology International is the official English journal of the Japanese Society of Pathology, publishing articles of excellence in human and experimental pathology. The Journal focuses on the morphological study of the disease process and/or mechanisms. For human pathology, morphological investigation receives priority but manuscripts describing the result of any ancillary methods (cellular, chemical, immunological and molecular biological) that complement the morphology are accepted. Manuscript on experimental pathology that approach pathologenesis or mechanisms of disease processes are expected to report on the data obtained from models using cellular, biochemical, molecular biological, animal, immunological or other methods in conjunction with morphology. Manuscripts that report data on laboratory medicine (clinical pathology) without significant morphological contribution are not accepted.