Prognostic Role of Neutrophil to Lymphocyte Ratio in Contrast-Induced Nephropathy: A Systematic Review and Meta-analysis.

IF 2.2 3区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Angiology Pub Date : 2025-10-01 Epub Date: 2024-03-15 DOI:10.1177/00033197241238512
Tao He, Behnood Mohammadpour, Matthew Willman, Shirin Yaghoobpoor, Jonathan Willman, Brandon Lucke-Wold, Sarina Aminizadeh, Shokoufeh Khanzadeh, Aida Bazrgar, Arshin Ghaedi
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Abstract

This meta-analysis assessed the use of the neutrophil-to-lymphocyte ratio (NLR) as a means of early detection of contrast-induced nephropathy (CIN) following diagnostic or therapeutic procedures. We used Web of Science, PubMed, and Scopus to conduct a systematic search. There was no limitation regarding language or date of publication. We reported standardized mean difference (SMD) with a 95% confidence interval (CI). Due to high heterogeneity, a random-effects model was used, and the Newcastle-Ottawa scale was used for quality assessment. Thirty-one articles were included in the analysis. Patients in the CIN group had elevated levels of NLR compared with those in the non-CIN group (SMD = 0.78, 95% CI = 0.52-1.04, P < .001). Similar results were observed in either prospective (SMD = 1.03, 95% CI = 0.13-1.93, P = .02) or retrospective studies (SMD = 0.70, 95% CI = 0.45-0.96, P < .001). The pooled sensitivity of NLR was 74.02% (95% CI = 66.54%-81.02%), and the pooled specificity was 60.58% (95% CI = 53.94%-66.84%). NLR shows potential as a cost-effective biomarker for predicting CIN associated with contrast-involved treatments. This could help implement timely interventions to mitigate CIN and improve outcomes.

中性粒细胞与淋巴细胞比值在造影剂诱发肾病中的预后作用:系统回顾与元分析》。
本荟萃分析评估了中性粒细胞与淋巴细胞比值(NLR)作为诊断或治疗程序后早期检测造影剂诱发肾病(CIN)的一种手段。我们使用 Web of Science、PubMed 和 Scopus 进行了系统检索。没有语言或发表日期的限制。我们报告了标准化平均差(SMD)及 95% 置信区间(CI)。由于异质性较高,我们采用了随机效应模型,并使用纽卡斯尔-渥太华量表进行质量评估。31篇文章被纳入分析。与非 CIN 组患者相比,CIN 组患者的 NLR 水平较高(SMD = 0.78,95% CI = 0.52-1.04,P < .001)。在前瞻性研究(SMD = 1.03,95% CI = 0.13-1.93,P = .02)或回顾性研究(SMD = 0.70,95% CI = 0.45-0.96,P < .001)中也观察到类似的结果。NLR 的汇总敏感性为 74.02%(95% CI = 66.54%-81.02%),汇总特异性为 60.58%(95% CI = 53.94%-66.84%)。NLR显示出作为预测与造影剂介入治疗相关的CIN的一种具有成本效益的生物标志物的潜力。这有助于及时采取干预措施,减轻 CIN 的病情并改善预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Angiology
Angiology 医学-外周血管病
CiteScore
5.50
自引率
14.30%
发文量
180
审稿时长
6-12 weeks
期刊介绍: A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days
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