A study on influence of wettability on antiviral coating using polyethylene glycol (PEG) and acrylic binder

IF 1.7 4区工程技术 Q4 POLYMER SCIENCE

Journal of Polymer Engineering Pub Date : 2024-03-12 DOI:10.1515/polyeng-2023-0263

Reasmyraj R. Subramaniam, Amirul Syafiq, Vengadaesvaran Balakrishnan, Muhammad Shakeel Ahmad, Nasrudin Abd Rahim, Pouya Hassandarvish

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引用次数: 0

Abstract

One of the biggest problems facing medical science today is preventing viral outbreaks, which highlights the significance of research initiatives aimed at creating antimicrobial coatings for a range of products, including textiles, medical devices, and public spaces. In this study, we aimed to determine the possible antiviral effects of polyethylene glycol (PEG) coating on feline coronavirus (FCoV). The PEG coatings were synthesized by a simple mixing method with a water-based acrylic binder in different weight percentages (3, 5, 10, 15, 20, and 25 wt%). The Spearman–Karber technique was used to calculate the viral titers, which were then expressed as the tissue culture infectious dose at 50 % CPE (TCID50/ml). 20 wt% PEG could result in a 3 log10 reduction in virus titer with an inhibition rate of approximately 99.9 % against FCoV. The increment of PEG weight percent from 0 to 25 wt% decreases the hardness and glass transition temperature of the coatings from 38.1 to 5.5 HV and 15.45 to −15.48 °C. Apart from that, the wettability analysis has revealed that PEG coating is hydrophilic with water contact angle (WCA) of around 75 ± 0.5°–85 ± 0.5°. Adding 25 wt% of PEG makes the coating to be superhydrophilic with WCA of 39.85 ± 0.5°.

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使用聚乙二醇（PEG）和丙烯酸粘合剂对抗病毒涂层润湿性影响的研究

当今医学科学面临的最大问题之一就是防止病毒爆发，这就凸显了旨在为纺织品、医疗设备和公共场所等一系列产品制作抗菌涂层的研究计划的重要性。在这项研究中，我们旨在确定聚乙二醇（PEG）涂层对猫冠状病毒（FCoV）可能产生的抗病毒作用。PEG 涂层是通过简单的混合方法与不同重量百分比（3、5、10、15、20 和 25 wt%）的水基丙烯酸粘合剂合成的。采用斯皮尔曼-卡伯技术计算病毒滴度，然后用 50% CPE 时的组织培养感染剂量（TCID50/ml）表示。20 重量百分比的 PEG 可使病毒滴度降低 3 log10，对 FCoV 的抑制率约为 99.9%。PEG 重量百分比从 0 增加到 25 wt%，涂层的硬度和玻璃化转变温度分别从 38.1 HV 和 15.45°C 降低到 5.5 HV 和 -15.48°C 。此外，润湿性分析表明，PEG 涂层具有亲水性，水接触角 (WCA) 约为 75 ± 0.5°-85 ± 0.5°。加入 25 wt% 的 PEG 后，涂层具有超亲水性，水接触角为 39.85 ± 0.5°。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Polymer Engineering 工程技术-高分子科学

CiteScore

3.20

自引率

5.00%

发文量

审稿时长

2.5 months

期刊介绍： Journal of Polymer Engineering publishes reviews, original basic and applied research contributions as well as recent technological developments in polymer engineering. Polymer engineering is a strongly interdisciplinary field and papers published by the journal may span areas such as polymer physics, polymer processing and engineering of polymer-based materials and their applications. The editors and the publisher are committed to high quality standards and rapid handling of the peer review and publication processes.