Evaluation on safety and efficacy of ultrasound assisted thrombolysis in a sheep artificial heart pump

IF 5.3 2区医学 Q1 ENGINEERING, BIOMEDICAL

Biocybernetics and Biomedical Engineering Pub Date : 2024-03-13 DOI:10.1016/j.bbe.2024.02.003

Yongchun Cui , Xiaobing Zheng , Shuo Wang , Jianye Zhou , Guangxin Yue , Peng Peng , Qiuju Li , Jubo Li , Yue Li , Jiafei Luo , Qi Zhang , Xue Zhang , Yongjian Li , Xin Wang

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Abstract

Thrombosis is a major and serious complication in patients with artificial heart pump assist device (HPAD). There is an urgent need for an efficient and safe method to solve the clinical challenge. We have developed a new type of ultrasound integrated heart pump assist device (uHPAD) with a pair of ultrasonic transducer rings installed around the pump. Based on the in-vitro experiments, the sonothrombolysis protocol was determined. Then, in-vivo experiments were performed on sheep to evaluate the efficacy and safety of the novel uHPAD. It is found that the ultrasound assisted thrombolysis with the drug-loaded microbubbles can accelerate the dissolution of the thrombus in the pump, while have no significant negative effect on blood cell components, coagulation-hemolysis system, and the structure and function of main organs. The ultrasound assisted thrombolysis is demonstrated to be a promising method to solve the clinical problem of thrombosis in the HPAD.

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评估超声波辅助绵羊人工心脏泵溶栓的安全性和有效性

血栓形成是人工心脏泵辅助装置（HPAD）患者的一个主要且严重的并发症。目前迫切需要一种高效、安全的方法来解决这一临床难题。我们开发了一种新型超声集成心脏泵辅助装置（uHPAD），在泵周围安装了一对超声换能器环。在体外实验的基础上，确定了超声溶栓方案。然后，在绵羊身上进行了体内实验，以评估新型超高压泵的有效性和安全性。实验发现，超声辅助溶栓与药物微泡一起使用，能加速泵内血栓的溶解，同时对血细胞成分、凝血溶血系统以及主要器官的结构和功能没有明显的负面影响。超声辅助溶栓被证明是解决HPAD血栓形成临床问题的一种可行方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biocybernetics and Biomedical Engineering ENGINEERING, BIOMEDICAL-

CiteScore

16.50

自引率

6.20%

发文量

审稿时长

38 days

期刊介绍： Biocybernetics and Biomedical Engineering is a quarterly journal, founded in 1981, devoted to publishing the results of original, innovative and creative research investigations in the field of Biocybernetics and biomedical engineering, which bridges mathematical, physical, chemical and engineering methods and technology to analyse physiological processes in living organisms as well as to develop methods, devices and systems used in biology and medicine, mainly in medical diagnosis, monitoring systems and therapy. The Journal''s mission is to advance scientific discovery into new or improved standards of care, and promotion a wide-ranging exchange between science and its application to humans.