Basin-scale exposure risk of psychiatric pharmaceuticals and illicit drugs in tap water in Eastern China

IF 5.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Emerging Contaminants Pub Date : 2024-03-09 DOI:10.1016/j.emcon.2024.100330

Wei Wang , Zeyuan Wang , Feng Chen , Fangxing Yang

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Abstract

A total of twenty-three psychiatric pharmaceuticals and illicit drugs were analyzed in tap water covering seven basins in Eastern China. The residual concentrations of these substances were detected up to 22.4 ng L^-1. Among the substances, benzodiazepines were more often detected with higher median concentrations than those of illicit drugs. Generally, the higher residual levels of psychoactive substances were detected in the upstream of the basins compared with the downstream. For example, the concentrations of diazepam, temazepam, and oxazepam in the downstream were much higher than those in the upstream in OJ. Among the basins, YH was the most polluted region. Exposure assessment indicated the median exposure doses of diazepam and temazepam were from 85 to 99 and 3.5–4.1 pg kg^-1 bw d^-1 in the basins, respectively. Benchmark quotient for the nine detected substances was calculated in each basin with the range from 0.0001 to 0.0389, indicating low risk in the tap water for human health under current concentrations.

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华东地区自来水中精神药物和违禁药物的基线暴露风险

对华东地区七个流域的自来水中的 23 种精神药物和违禁药物进行了分析。这些物质的残留浓度最高可达 22.4 纳克/升。在这些物质中，苯二氮卓类药物的检出率较高，中位浓度高于违禁药物。一般来说，与下游相比，流域上游检测到的精神活性物质残留量更高。例如，在 OJ，地西泮、替马西泮和奥沙西泮在下游的浓度远高于在上游的浓度。在各流域中，YH 是污染最严重的地区。暴露评估显示，各流域地西泮和替马西泮的暴露剂量中位数分别为 85 至 99 皮克/千克-1 体重/天和 3.5 至 4.1 皮克/千克-1 体重/天。在每个流域计算出的九种被检测物质的基准商数范围为 0.0001 至 0.0389，表明在当前浓度下，自来水对人体健康的风险较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Contaminants Medicine-Public Health, Environmental and Occupational Health

CiteScore

10.00

自引率

6.70%

发文量

审稿时长

44 days

期刊介绍： Emerging Contaminants is an outlet for world-leading research addressing problems associated with environmental contamination caused by emerging contaminants and their solutions. Emerging contaminants are defined as chemicals that are not currently (or have been only recently) regulated and about which there exist concerns regarding their impact on human or ecological health. Examples of emerging contaminants include disinfection by-products, pharmaceutical and personal care products, persistent organic chemicals, and mercury etc. as well as their degradation products. We encourage papers addressing science that facilitates greater understanding of the nature, extent, and impacts of the presence of emerging contaminants in the environment; technology that exploits original principles to reduce and control their environmental presence; as well as the development, implementation and efficacy of national and international policies to protect human health and the environment from emerging contaminants.

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