Impact of Smoking on Coronary Volume-to-Myocardial Mass Ratio: An ADVANCE Registry Substudy.
IF 3.8
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Kenneth R Holmes, Gaurav S Gulsin, Timothy A Fairbairn, Lynne Hurwitz-Koweek, Hitoshi Matsuo, Bjarne L Nørgaard, Jesper M Jensen, Niels-Peter Rønnow Sand, Koen Nieman, Jeroen J Bax, Gianluca Pontone, Kavitha M Chinnaiyan, Mark G Rabbat, Tetsuya Amano, Tomohiro Kawasaki, Takashi Akasaka, Hironori Kitabata, Campbell Rogers, Manesh R Patel, Geoffrey W Payne, Jonathon A Leipsic, Stephanie L Sellers
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Abstract
Purpose To examine the relationship between smoking status and coronary volume-to-myocardial mass ratio (V/M) among individuals with coronary artery disease (CAD) undergoing CT fractional flow reserve (CT-FFR) analysis. Materials and Methods In this secondary analysis, participants from the ADVANCE registry evaluated for suspected CAD from July 15, 2015, to October 20, 2017, who were found to have coronary stenosis of 30% or greater at coronary CT angiography (CCTA) were included if they had known smoking status and underwent CT-FFR and V/M analysis. CCTA images were segmented to calculate coronary volume and myocardial mass. V/M was compared between smoking groups, and predictors of low V/M were determined. Results The sample for analysis included 503 current smokers, 1060 former smokers, and 1311 never-smokers (2874 participants; 1906 male participants). After adjustment for demographic and clinical factors, former smokers had greater coronary volume than never-smokers (former smokers, 3021.7 mm3 ± 934.0 [SD]; never-smokers, 2967.6 mm3 ± 978.0; P = .002), while current smokers had increased myocardial mass compared with never-smokers (current smokers, 127.8 g ± 32.9; never-smokers, 118.0 g ± 32.5; P = .02). However, both current and former smokers had lower V/M than never-smokers (current smokers, 24.1 mm3 /g ± 7.9; former smokers, 24.9 mm3 /g ± 7.1; never-smokers, 25.8 mm3 /g ± 7.4; P < .001 [unadjusted] and P = .002 [unadjusted], respectively). Current smoking status (odds ratio [OR], 0.74 [95% CI: 0.59, 0.93]; P = .009), former smoking status (OR, 0.81 [95% CI: 0.68, 0.97]; P = .02), stenosis of 50% or greater (OR, 0.62 [95% CI: 0.52, 0.74]; P < .001), and diabetes (OR, 0.67 [95% CI: 0.56, 0.82]; P < .001) were independent predictors of low V/M. Conclusion Both current and former smoking status were independently associated with low V/M. Keywords: CT Angiography, Cardiac, Heart, Ischemia/Infarction Clinical trial registration no. NCT02499679 Supplemental material is available for this article . © RSNA, 2024.
吸烟对冠状动脉容积-心肌质量比的影响:一项 ADVANCE 注册子研究。
目的 研究接受 CT 分形血流储备(CT-FFR)分析的冠状动脉疾病(CAD)患者中吸烟状态与冠状动脉体积-心肌质量比(V/M)之间的关系。材料与方法 在这项二次分析中,纳入了从 2015 年 7 月 15 日至 2017 年 10 月 20 日期间因疑似 CAD 而接受 ADVANCE 登记评估的参与者,这些参与者在冠状动脉 CT 血管造影(CCTA)中被发现冠状动脉狭窄达到或超过 30%,如果他们已知吸烟状态并接受了 CT-FFR 和 V/M 分析。对 CCTA 图像进行分割,以计算冠状动脉容积和心肌质量。比较不同吸烟组的 V/M,并确定低 V/M 的预测因素。结果 分析样本包括 503 名当前吸烟者、1060 名曾经吸烟者和 1311 名从不吸烟者(2874 名参与者;1906 名男性参与者)。在对人口统计学和临床因素进行调整后,曾经吸烟者的冠状动脉容积大于从不吸烟者(曾经吸烟者,3021.7 mm3 ± 934.0 [SD]; 从不吸烟者,2967.6 mm3 ± 978.0; P = .002),而现在吸烟者的心肌质量大于从不吸烟者(现在吸烟者,127.8 g ± 32.9; 从不吸烟者,118.0 g ± 32.5; P = .02)。然而,当前吸烟者和曾经吸烟者的 V/M 值均低于从不吸烟者(当前吸烟者,24.1 mm3/g ± 7.9;曾经吸烟者,24.9 mm3/g ± 7.1;从不吸烟者,25.8 mm3/g ± 7.4;P < .001 [未调整] 和 P = .002 [未调整])。当前吸烟状态(几率比 [OR],0.74 [95% CI:0.59, 0.93];P = .009)、曾经吸烟状态(OR,0.81 [95% CI:0.68, 0.97];P = .02)、狭窄程度达到或超过 50%(OR,0.62 [95% CI:0.52, 0.74];P < .001)和糖尿病(OR,0.67 [95% CI:0.56, 0.82];P < .001)是低 V/M 的独立预测因素。结论 目前和以前的吸烟状况都与低V/M独立相关。关键词CT血管造影 心脏 心脏缺血/梗死 临床试验注册号本文有补充材料。© RSNA, 2024.
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