Significant association of HLA-A26 with uveitis and gastrointestinal involvement in patients with Behçet's disease in a multicentre study.

IF 1.8 4区 医学 Q3 RHEUMATOLOGY
Tomoya Nakajima, Hideaki Tsuji, Ryuta Inaba, Rintaro Saito, Keisuke Nishimura, Akio Morinobu
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引用次数: 0

Abstract

Objectives: Specific human leukocyte antigen (HLA) haplotypes are associated with Behçet's disease. Because the effects of HLA-A26 and its combination with HLA-B51 on organ involvement in Behçet's disease have not been well demonstrated, we aimed to examine them.

Methods: This multicentre, cross-sectional, observational study enrolled patients with Behçet's disease who visited Kyoto University Hospital between 2018 and 2021 or Kurashiki Central Hospital between 2006 and 2016 (n = 200). Disease severity was evaluated using the Krause score.

Results: Uveitis and gastrointestinal involvement were observed in 95/196 and 57/167 patients, respectively. The HLA alleles identified were HLA-B51 (n = 52/106), HLA-A26 (n = 25/88), and HLA-B51 and HLA-A26 (n = 6/88). In patients harbouring HLA-B51, the presence of HLA-A26 was associated with higher frequencies of uveitis (P = .03) and coexistence of uveitis and gastrointestinal involvement (P = .002) and higher Krause scores (P = .02). Furthermore, the presence of HLA-A26 was associated with a higher frequency of uveitis in patients with gastrointestinal involvement (P = .001) and gastrointestinal involvement in patients with uveitis (P = .001).

Conclusions: Since specific HLA haplotypes and their combinations are associated with organ involvement, both HLA-A and HLA-B haplotypes should be confirmed when screening for affected organs.

一项多中心研究发现,HLA-A26 与贝赫切特病患者的葡萄膜炎和胃肠道受累密切相关。
目的:特定的 HLA 单倍型与白塞氏病(BD)有关。由于 HLA-A26 及其与 HLA-B51 的组合对 BD 器官受累的影响尚未得到充分证实,我们旨在对其进行研究:这项多中心、横断面、观察性研究招募了2018年至2021年期间在京都大学医院或2006年至2016年期间在仓敷中央医院就诊的BD患者(n = 200)。采用克劳斯评分法评估疾病严重程度:分别有95/196和57/167名患者出现葡萄膜炎和胃肠道受累。HLA等位基因分别为HLA-B51(52/106)、HLA-A26(25/88)、HLA-B51和HLA-A26(6/88)。在携带HLA-B51的患者中,HLA-A26的存在与葡萄膜炎(p = 0.03)、葡萄膜炎和胃肠道受累并存(p = 0.002)以及较高的Krause评分(p = 0.02)相关。此外,HLA-A26的存在与葡萄膜炎患者胃肠道受累(p = 0.001)和葡萄膜炎患者胃肠道受累(p = 0.001)的频率较高有关:结论:由于特定的 HLA 单倍型及其组合与受累器官有关,因此在筛查受累器官时应同时确认 HLA-A 和 HLA-B 单倍型。
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来源期刊
Modern Rheumatology
Modern Rheumatology RHEUMATOLOGY-
CiteScore
4.90
自引率
9.10%
发文量
146
审稿时长
1.5 months
期刊介绍: Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery. Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered. Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions
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