{"title":"Acute Viral Hepatitis E Infection Complicating Postliving Liver Donor Hepatectomy Recovery","authors":"Kaleem Ullah, Sidhant Ochani, Hafiz B. Ahmad","doi":"10.1016/j.jceh.2024.101389","DOIUrl":null,"url":null,"abstract":"<div><p>This study presents a case of a living liver donor who developed a hepatitis E virus (HEV) infection postdonation, complicating his recovery. The donor was a 28-year-old male with no prior health issues who underwent a right lobe hepatectomy. Initially, his postoperative course was uneventful, but on the third postoperative day, he became lethargic and icteric. Laboratory tests showed elevated liver function markers, with peak levels on the 5th day. The HEV infection was confirmed through serological and polymerase chain reaction (PCR) testing. The donor was managed supportively and recovered, with normal liver function at discharge. Unfortunately, the recipient of the liver graft died on the 5th postoperative day due to sepsis, and the impact of HEV infection on the recipient could not be fully assessed due to the complicating factors. This case highlights the importance of considering HEV infection in donors with abnormal postoperative liver functions, especially in regions with high HEV prevalence, and suggests the potential benefit of HEV vaccination for liver donors. Further research is needed to better understand and manage HEV infection in the context of liver donation.</p></div>","PeriodicalId":15479,"journal":{"name":"Journal of Clinical and Experimental Hepatology","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical and Experimental Hepatology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S097368832400046X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This study presents a case of a living liver donor who developed a hepatitis E virus (HEV) infection postdonation, complicating his recovery. The donor was a 28-year-old male with no prior health issues who underwent a right lobe hepatectomy. Initially, his postoperative course was uneventful, but on the third postoperative day, he became lethargic and icteric. Laboratory tests showed elevated liver function markers, with peak levels on the 5th day. The HEV infection was confirmed through serological and polymerase chain reaction (PCR) testing. The donor was managed supportively and recovered, with normal liver function at discharge. Unfortunately, the recipient of the liver graft died on the 5th postoperative day due to sepsis, and the impact of HEV infection on the recipient could not be fully assessed due to the complicating factors. This case highlights the importance of considering HEV infection in donors with abnormal postoperative liver functions, especially in regions with high HEV prevalence, and suggests the potential benefit of HEV vaccination for liver donors. Further research is needed to better understand and manage HEV infection in the context of liver donation.
本研究介绍了一例活体肝脏捐献者,他在捐献后感染了戊型肝炎病毒(HEV),这使他的康复变得更加复杂。捐献者是一名 28 岁的男性,之前没有任何健康问题,接受了右叶肝切除术。最初,他的术后过程并无大碍,但在术后第三天,他开始嗜睡并出现黄疸。实验室检查显示肝功能指标升高,第 5 天达到峰值。通过血清学和聚合酶链反应(PCR)检测证实了 HEV 感染。捐献者经过支持性治疗后康复出院,出院时肝功能正常。不幸的是,肝脏移植的受体在术后第 5 天因败血症死亡,由于并发症因素,无法全面评估 HEV 感染对受体的影响。本病例强调了在术后肝功能异常的供体中考虑 HEV 感染的重要性,尤其是在 HEV 感染率较高的地区,并提示了肝脏供体接种 HEV 疫苗的潜在益处。要更好地了解和处理肝脏捐献中的 HEV 感染,还需要进一步的研究。