Royal Jelly, A Super Food, Protects Against Celecoxib-Induced Renal Toxicity in Adult Male Albino Rats.

IF 1.6 Q3 UROLOGY & NEPHROLOGY

Canadian Journal of Kidney Health and Disease Pub Date : 2024-03-10 eCollection Date: 2024-01-01 DOI:10.1177/20543581241235526

Hesham A M I Khalifa, Naglaa Z H Eleiwa, Heba A Nazim

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Abstract

Background: Celecoxib is a COX-2 nonsteroidal anti-inflammatory drug (NSAID). It is widely used for the treatment of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.

Objective: This study aimed to explore the effect of long-term administration of celecoxib on kidney of male albino rats, and to study the potential effect of treatment discontinuation on such tissues. The study also examined the alleged ameliorative effect of royal jelly (RJ).

Methods: Fifty, male albino rats were divided into 5 equal groups; 10 each. Group 1: rats received no drug (control group). Group 2: rats received celecoxib (50 mg/kg/day, orally for 30 successive days). Group 3: rats received celecoxib (50 mg/kg/day, orally) and royal jelly (300 mg/kg/day, orally) for 30 successive days. Group 4: rats received celecoxib for 30 successive days, then rats were left untreated for another 30 days. Group 5: rats received celecoxib and RJ for 30 successive days, then rats were left untreated for another 30 days.

Results: Long-term celecoxib administration caused significant elevation in kidney function tests, with ameliorative effects of RJ against celecoxib-induced renal toxicity.

Conclusion: Long-term celecoxib administration caused renal toxicity in male albino rats, with ameliorative effects of RJ.

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蜂王浆--一种超级食品--可保护成年雄性白化大鼠免受塞来昔布诱发的肾毒性影响

背景：塞来昔布是一种 COX-2 非甾体抗炎药（NSAID）：塞来昔布是一种 COX-2 非甾体抗炎药（NSAID）。它被广泛用于治疗骨关节炎、类风湿性关节炎和强直性脊柱炎：本研究旨在探讨长期服用塞来昔布对雄性白化大鼠肾脏的影响，并研究停止治疗对这些组织的潜在影响。研究还探讨了蜂王浆（RJ）的所谓改善作用：将 50 只雄性白化大鼠分成 5 组，每组 10 只。第 1 组：大鼠不服药（对照组）。第 2 组：大鼠连续 30 天口服塞来昔布（50 毫克/千克/天）。第 3 组：大鼠连续 30 天口服塞来昔布（50 毫克/千克/天）和蜂王浆（300 毫克/千克/天）。第 4 组：连续 30 天给大鼠服用塞来昔布，然后再给大鼠服用 30 天。第 5 组：连续 30 天给大鼠服用塞来昔布和 RJ，然后再连续 30 天不给大鼠服用：结果：长期服用塞来昔布会导致肾功能检测指标显著升高，而 RJ 可改善塞来昔布引起的肾毒性：结论：长期服用塞来昔布会导致雄性白化大鼠肾脏中毒，而 RJ 具有改善作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Canadian Journal of Kidney Health and Disease Medicine-Nephrology

CiteScore

3.00

自引率

5.90%

发文量

审稿时长

12 weeks

期刊介绍： Canadian Journal of Kidney Health and Disease, the official journal of the Canadian Society of Nephrology, is an open access, peer-reviewed online journal that encourages high quality submissions focused on clinical, translational and health services delivery research in the field of chronic kidney disease, dialysis, kidney transplantation and organ donation. Our mandate is to promote and advocate for kidney health as it impacts national and international communities. Basic science, translational studies and clinical studies will be peer reviewed and processed by an Editorial Board comprised of geographically diverse Canadian and international nephrologists, internists and allied health professionals; this Editorial Board is mandated to ensure highest quality publications.