Effects of Age on the Frequency Amplitude Ratio of Cervical and Ocular Vestibular Evoked Myogenic Potentials.

IF 1.4 4区医学 Q3 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

American Journal of Audiology Pub Date : 2024-06-04 Epub Date: 2024-03-12 DOI:10.1044/2024_AJA-23-00253

Raghav H Jha, Erin G Piker, Jesus Gomez

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引用次数: 0

Abstract

Purpose: An increase in the 1000/500 Hz frequency amplitude ratio (FAR) of the cervical and ocular vestibular evoked myogenic potentials (cVEMP and oVEMP, respectively) may serve as a potential biomarker for diagnosing Meniere's disease (MD). However, the aging process can also result in an increased FAR for VEMPs. In older patients, distinguishing whether changes in VEMP FAR are due to MD or aging processes becomes difficult. We aimed to investigate the effects of age on VEMP FARs and establish a FAR-normative range for different age groups.

Method: cVEMP and oVEMP were recorded from a total of 106 participants grouped as young, middle-aged, and older adults using air-conducted tone bursts at 500, 750, and 1000 Hz at 125 dB pSPL. The FAR was calculated for the cVEMP and oVEMP for the following frequencies: FAR1 = 1000/500, FAR2 = 1000/750, and FAR3 = 750/500.

Results: A significant age-related effect was observed on the cVEMP FAR. Although the oVEMP FAR showed an increasing trend with age, it was not statistically significant. Age-based normative FAR values are provided.

Conclusions: Drawing from the normative FAR from this study, there is evidence that the existing MD diagnostic criteria would misidentify a considerable number of older adults. Therefore, to reduce false positives, we recommend a more stringent cVEMP and oVEMP FAR criterion in older adults.

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年龄对颈前庭和眼前庭诱发肌源性电位频率振幅比的影响

目的：颈部和眼部前庭诱发肌源性电位（分别为 cVEMP 和 oVEMP）的 1000/500 Hz 频率振幅比（FAR）增加可作为诊断梅尼埃病（MD）的潜在生物标志物。然而，衰老过程也会导致 VEMP 的 FAR 增加。在老年患者中，区分 VEMP FAR 的变化是由 MD 还是衰老过程引起的变得十分困难。我们的目的是研究年龄对 VEMP FAR 的影响，并确定不同年龄组的 FAR 标准范围。方法：使用频率为 500、750 和 1000 Hz、125 dB pSPL 的导气音脉冲串，记录 106 名参与者的 cVEMP 和 oVEMP，将其分为年轻人、中年人和老年人组。计算了以下频率的 cVEMP 和 oVEMP 的 FAR：FAR1 = 1000/500，FAR2 = 1000/750，FAR3 = 750/500：结果：在 cVEMP FAR 上观察到了明显的年龄相关效应。虽然 oVEMP FAR 随年龄呈上升趋势，但在统计学上并不显著。提供了基于年龄的标准 FAR 值：根据本研究中的常模 FAR 值，有证据表明现有的 MD 诊断标准会误诊相当数量的老年人。因此，为了减少误诊，我们建议对老年人采用更严格的 cVEMP 和 oVEMP FAR 标准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Audiology AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY-OTORHINOLARYNGOLOGY

CiteScore

3.00

自引率

16.70%

发文量

163

审稿时长

>12 weeks

期刊介绍： Mission: AJA publishes peer-reviewed research and other scholarly articles pertaining to clinical audiology methods and issues, and serves as an outlet for discussion of related professional and educational issues and ideas. The journal is an international outlet for research on clinical research pertaining to screening, diagnosis, management and outcomes of hearing and balance disorders as well as the etiologies and characteristics of these disorders. The clinical orientation of the journal allows for the publication of reports on audiology as implemented nationally and internationally, including novel clinical procedures, approaches, and cases. AJA seeks to advance evidence-based practice by disseminating the results of new studies as well as providing a forum for critical reviews and meta-analyses of previously published work. Scope: The broad field of clinical audiology, including audiologic/aural rehabilitation; balance and balance disorders; cultural and linguistic diversity; detection, diagnosis, prevention, habilitation, rehabilitation, and monitoring of hearing loss; hearing aids, cochlear implants, and hearing-assistive technology; hearing disorders; lifespan perspectives on auditory function; speech perception; and tinnitus.