Inflammatory sensory neuronopathies

IF 2.8 4区医学 Q2 CLINICAL NEUROLOGY

Revue neurologique Pub Date : 2024-12-01 DOI:10.1016/j.neurol.2023.12.012

J.-C. Antoine

引用次数: 0

Abstract

Inflammatory sensory neuronopathies are rare disorders mediated by dysimmune mechanisms targeting sensory neurons in the dorsal root ganglia. They constitute a heterogeneous group of disorders with acute, subacute, or chronic courses, and occur with cancer, systemic autoimmune diseases, notably Sjögren syndrome, and viral infections but a noticeable proportion of them remains isolated. Identifying inflammatory sensory neuronopathies is crucial because they have the potential to be stabilized or even to improve with immunomodulatory or immunosuppressant treatments provided that the treatment is applied at an early stage of the disease, before a definitive degeneration of neurons. Biomarkers, and notably antibodies, are crucial for this early identification, which is the first step to develop therapeutic trials.

查看原文本刊更多论文

炎症性感觉神经元病。

炎症性感觉神经元病是由针对背根神经节感觉神经元的免疫异常机制介导的罕见疾病。它们是一组具有急性、亚急性或慢性病程的异质性疾病，与癌症、系统性自身免疫性疾病（尤其是斯约格伦综合征）和病毒感染同时发生，但其中仍有相当一部分是孤立存在的。鉴别炎症性感觉神经元病至关重要，因为只要在疾病的早期阶段，即在神经元发生明确的变性之前采用免疫调节或免疫抑制剂治疗，炎症性感觉神经元病就有可能得到稳定甚至改善。生物标志物，尤其是抗体，对于这种早期识别至关重要，而这正是开展治疗试验的第一步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Revue neurologique 医学-临床神经学

CiteScore

4.80

自引率

0.00%

发文量

598

审稿时长

55 days

期刊介绍： The first issue of the Revue Neurologique, featuring an original article by Jean-Martin Charcot, was published on February 28th, 1893. Six years later, the French Society of Neurology (SFN) adopted this journal as its official publication in the year of its foundation, 1899. The Revue Neurologique was published throughout the 20th century without interruption and is indexed in all international databases (including Current Contents, Pubmed, Scopus). Ten annual issues provide original peer-reviewed clinical and research articles, and review articles giving up-to-date insights in all areas of neurology. The Revue Neurologique also publishes guidelines and recommendations. The Revue Neurologique publishes original articles, brief reports, general reviews, editorials, and letters to the editor as well as correspondence concerning articles previously published in the journal in the correspondence column.