The roles of sex hormones in the pathophysiology of age-related sarcopenia and frailty.

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Reproductive Medicine and Biology Pub Date : 2024-03-11 eCollection Date: 2024-01-01 DOI:10.1002/rmb2.12569

Tatsuya Hosoi, Mitsutaka Yakabe, Seiji Hashimoto, Masahiro Akishita, Sumito Ogawa

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引用次数: 0

Abstract

Background: Sarcopenia is an age-related condition characterized by a progressive and systemic decline in skeletal muscle mass, quality, and strength. The incidence of sarcopenia contains sex-specific aspects, indicating the contribution of sex hormones to its pathophysiology. This review focuses on changing trends in sarcopenia, discusses alterations in definitions and diagnostic criteria, and emphasizes the association between sarcopenia and sex hormones.

Methods: A literature search was performed on PubMed for related articles published between 1997 and December 2023 using appropriate keywords.

Main findings results: Advances in research have emphasized the significance of muscle quality and strength over muscle mass, resulting in new diagnostic criteria for sarcopenia. Androgens demonstrated anabolic effects on skeletal muscles and played a significant role in the pathophysiology of sarcopenia. In clinical settings, androgen replacement therapy has exhibited certain positive outcomes for treating sarcopenia, despite concerns about potential side effects. Conversely, estrogen is involved in skeletal muscle maintenance, but the detailed mechanisms remain unclear. Moreover, results regarding the clinical application of estrogen replacement therapy for treating sarcopenia remained inconsistent.

Conclusion: The elucidation of molecular mechanisms that involve sex hormones is eagerly awaited for novel therapeutic interventions for sarcopenia.

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性激素在与年龄相关的肌肉疏松症和虚弱的病理生理学中的作用。

背景：肌肉疏松症是一种与年龄有关的疾病，其特征是骨骼肌质量、质量和力量的逐渐和系统性下降。肌肉疏松症的发病率具有性别特异性，表明性激素对其病理生理学有一定影响。本综述重点关注肌肉疏松症的变化趋势，讨论定义和诊断标准的变化，并强调肌肉疏松症与性激素之间的关联：方法：使用适当的关键词在 PubMed 上检索 1997 年至 2023 年 12 月间发表的相关文章：研究进展强调了肌肉质量和力量的重要性，而非肌肉质量，从而为 "肌肉疏松症 "制定了新的诊断标准。雄激素对骨骼肌具有同化作用，在肌肉疏松症的病理生理学中扮演着重要角色。在临床上，尽管存在潜在的副作用，但雄激素替代疗法在治疗肌肉疏松症方面取得了一定的积极效果。相反，雌激素参与了骨骼肌的维护，但其详细机制仍不清楚。此外，临床应用雌激素替代疗法治疗肌肉疏松症的结果仍不一致：结论：阐明涉及性激素的分子机制，是治疗肌肉疏松症的新型干预措施的迫切期待。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Medicine and Biology Multiple-

CiteScore

5.70

自引率

5.90%

发文量

审稿时长

20 weeks

期刊介绍： Reproductive Medicine and Biology (RMB) is the official English journal of the Japan Society for Reproductive Medicine, the Japan Society of Fertilization and Implantation, the Japan Society of Andrology, and publishes original research articles that report new findings or concepts in all aspects of reproductive phenomena in all kinds of mammals. Papers in any of the following fields will be considered: andrology, endocrinology, oncology, immunology, genetics, function of gonads and genital tracts, erectile dysfunction, gametogenesis, function of accessory sex organs, fertilization, embryogenesis, embryo manipulation, pregnancy, implantation, ontogenesis, infectious disease, contraception, etc.