Alteration of serotonin release response in the central nucleus of the amygdala to noxious and non-noxious mechanical stimulation in a neuropathic pain model rat.

IF 2.6 4区医学 Q2 PHYSIOLOGY

Journal of Physiological Sciences Pub Date : 2024-03-12 DOI:10.1186/s12576-024-00910-x

Ryota Tokunaga, Hideshi Shibata, Mieko Kurosawa

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Abstract

Previously, we found that serotonin (5-HT) release in the central nucleus of the amygdala (CeA) of anesthetized rats decreases in response to innocuous stroking of the skin, irrespective of stimulus laterality, but increases in response to noxious pinching applied to a hindlimb contralateral to the 5-HT measurement site. The aim of the present study was to determine whether intra-CeA 5-HT release responses to cutaneous stimulation were altered in an animal model of neuropathic pain induced by ligation of the left L5 spinal nerve. In anesthetized neuropathic pain model rats, stroking of the left hindlimb increased 5-HT release in the CeA, whereas stroking of the right hindlimb decreased it. Meanwhile, pinching of the left hindlimb increased intra-CeA 5-HT release irrespective of stimulus laterality. In conclusion, the present study demonstrated that intra-CeA 5-HT release responses to cutaneous stimulation are altered in an animal model of neuropathic pain.

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神经性疼痛模型大鼠杏仁核中枢核对有毒和无毒机械刺激的血清素释放反应的改变

此前，我们发现麻醉大鼠杏仁核中央核（CeA）中的血清素（5-HT）释放会在皮肤受到无害抚摸时减少，与刺激侧位无关，但在5-HT测量点对侧的后肢受到刺激时会增加。本研究旨在确定在结扎左侧 L5 脊神经诱发的神经病理性疼痛动物模型中，CeA 内 5-HT 释放对皮肤刺激的反应是否会发生改变。在麻醉的神经病理性疼痛模型大鼠中，抚摸左后肢会增加 CeA 中 5-HT 的释放，而抚摸右后肢则会减少 CeA 中 5-HT 的释放。同时，无论刺激侧向如何，掐左后肢都会增加CeA内5-HT的释放。总之，本研究表明，在神经病理性疼痛动物模型中，CeA 内 5-HT 释放对皮肤刺激的反应发生了改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Physiological Sciences 医学-生理学

CiteScore

4.40

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of Physiological Sciences publishes peer-reviewed original papers, reviews, short communications, technical notes, and letters to the editor, based on the principles and theories of modern physiology and addressed to the international scientific community. All fields of physiology are covered, encompassing molecular, cellular and systems physiology. The emphasis is on human and vertebrate physiology, but comparative papers are also considered. The process of obtaining results must be ethically sound. Fields covered: Adaptation and environment Autonomic nervous function Biophysics Cell sensors and signaling Central nervous system and brain sciences Endocrinology and metabolism Excitable membranes and neural cell physiology Exercise physiology Gastrointestinal and kidney physiology Heart and circulatory physiology Molecular and cellular physiology Muscle physiology Physiome/systems biology Respiration physiology Senses.