New approaches to second-degree burn healing: Polyvinyl alcohol membrane loaded to arnica combined to laser therapy.

IF 2.3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Journal of Biomaterials Applications Pub Date : 2024-05-01 Epub Date: 2024-03-12 DOI:10.1177/08853282241238609

Carolina Silva Cardoso, Filipe Feitosa de Carvalho, Rodrigo César Gomes, Reinaldo José Gianini, Camilla Fanelli, Irene de Lourdes Noronha, Nelson Brancaccio Dos Santos, Daniel Komatsu, Priscila Randazzo-Moura

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引用次数: 0

Abstract

Second-degree burns require greater care, as the damage is more extensive and worrisome and the use of a biomaterial can help in the cell repair process, with better planning, low cost, and better accessibility. Arnica has anti-inflammatory and analgesic properties in skin lesions treatments and laser therapy is another therapeutic alternative for burns. Evaluate the effects of arnica incorporated into PVA associated or not with low intensity laser on burns in rats. PVA and PVA with arnica (PVA+A) were obtained and characterized physicochemically. Through in vivo studies, the effects of PVA and PVA+A with or without the application of laser on the lesions allowed histological and immunohistochemical analyzes. PVA+A was biocompatible and with sustained release of the active, being a promising pharmacological tool and confirmed that laser therapy was effective in accelerating the healing process, due to its potential biomodulator, improving inflammatory aspects, promoting rapid healing in skin lesions.

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二度烧伤愈合的新方法：含有山金车的聚乙烯醇膜与激光疗法相结合。

二度烧伤需要更多的护理，因为损伤范围更大，更令人担忧，而使用生物材料可以帮助细胞修复过程，具有更好的规划性、低成本和更好的可及性。山金车在皮肤病变治疗中具有消炎和镇痛作用，激光疗法是烧伤的另一种治疗选择。评估在 PVA 中加入山金车和低强度激光对大鼠烧伤的影响。获得了 PVA 和含有山金车的 PVA（PVA+A），并对其进行了物理化学表征。通过体内研究，对 PVA 和 PVA+A 在使用或不使用激光的情况下对病变的影响进行了组织学和免疫组化分析。PVA+A 具有生物相容性，可持续释放活性物质，是一种很有前途的药理学工具，并证实激光疗法能有效加速愈合过程，因为它是一种潜在的生物调节剂，能改善炎症反应，促进皮肤损伤的快速愈合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomaterials Applications 工程技术-材料科学：生物材料

CiteScore

5.10

自引率

3.40%

发文量

144

审稿时长

1.5 months

期刊介绍： The Journal of Biomaterials Applications is a fully peer reviewed international journal that publishes original research and review articles that emphasize the development, manufacture and clinical applications of biomaterials. Peer-reviewed articles by biomedical specialists from around the world cover: New developments in biomaterials, R&D, properties and performance, evaluation and applications Applications in biomedical materials and devices - from sutures and wound dressings to biosensors and cardiovascular devices Current findings in biological compatibility/incompatibility of biomaterials The Journal of Biomaterials Applications publishes original articles that emphasize the development, manufacture and clinical applications of biomaterials. Biomaterials continue to be one of the most rapidly growing areas of research in plastics today and certainly one of the biggest technical challenges, since biomaterial performance is dependent on polymer compatibility with the aggressive biological environment. The Journal cuts across disciplines and focuses on medical research and topics that present the broadest view of practical applications of biomaterials in actual clinical use. The Journal of Biomaterial Applications is devoted to new and emerging biomaterials technologies, particularly focusing on the many applications which are under development at industrial biomedical and polymer research facilities, as well as the ongoing activities in academic, medical and applied clinical uses of devices.