Population-based surveillance for birth defects potentially related to Zika virus infection including 3-year mortality and developmental outcomes, and Early Intervention Program service use—New York City, 2016 birth cohort

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2024-03-13 DOI:10.1002/bdr2.2320

Katharine H. McVeigh, Tenzin Tseyang, Mary-Elizabeth Vachon, Aurora Moraes

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引用次数: 0

Abstract

Background

In response to the 2015–2017 Zika virus outbreak, New York City (NYC) identified and monitored infants with birth defects potentially related to congenital Zika virus.

Methods

Administrative data matches were used to describe the birth characteristics of children born in 2016 meeting screening criteria for birth defects potentially related to congenital Zika virus infection relative to other NYC births and to monitor mortality and Early Intervention Program use through age 2.

Results

Among 120,367 children born in NYC in 2016, 463 met screening criteria and 155 met the Centers for Disease Control and Prevention's case definition for birth defects potentially related to congenital Zika virus infection (1.3 per 1000; 95% confidence interval [CI], 1.1–1.5). Post-neonatal deaths occurred among 7.7% of cases (12) and 5.2% of non-cases (8). Odds of referral to the Early intervention Program among children who met screening criteria were lower among children of mothers who were married (OR, 0.60; 95% CI, 0.37–0.97) and among children not classified as cases whose mothers were born in Latin America and the Caribbean (OR, 0.59; 95% CI, 0.37–1.09).

Discussion

Prevalence of birth defects potentially related to congenital Zika virus infection was similar to that seen in other jurisdictions without local transmission. Birth defects attributable to congenital Zika virus infection may also have been present among screened children who did not meet the case definition.

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对可能与寨卡病毒感染有关的出生缺陷进行基于人群的监测，包括 3 年死亡率和发育结果，以及早期干预计划服务的使用情况--纽约市，2016 年出生队列。

背景：为应对 2015-2017 年的寨卡病毒疫情，纽约市对可能与先天性寨卡病毒有关的出生缺陷婴儿进行了鉴定和监测：为应对 2015-2017 年的寨卡病毒疫情，纽约市（NYC）发现并监测了出生缺陷可能与先天性寨卡病毒有关的婴儿：方法：利用行政数据匹配来描述 2016 年出生的符合先天性寨卡病毒感染相关出生缺陷筛查标准的儿童与纽约市其他新生儿的出生特征，并监测死亡率和 2 岁前早期干预计划的使用情况：2016年在纽约市出生的120 367名儿童中，有463名符合筛查标准，155名符合美国疾病控制和预防中心对可能与先天性寨卡病毒感染有关的出生缺陷的病例定义（1.3‰；95%置信区间[CI]，1.1-1.5）。产后死亡病例占病例总数的 7.7%（12 例），占非病例总数的 5.2%（8 例）。在符合筛查标准的儿童中，母亲为已婚人士的儿童被转介到早期干预计划的几率较低（OR，0.60；95% CI，0.37-0.97），而母亲出生在拉丁美洲和加勒比海地区的未被归类为病例的儿童被转介到早期干预计划的几率较低（OR，0.59；95% CI，0.37-1.09）：讨论：可能与先天性寨卡病毒感染有关的出生缺陷发生率与其他未发生本地传播的地区相似。先天性寨卡病毒感染导致的出生缺陷也可能出现在不符合病例定义的筛查儿童中。

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来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.

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