The Level of Anti-Viral Antigen-Specific Antibodies to EBNA-1 in the Serum of MS Patients Does not Depend on the Severity of the Disease

IF 0.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Doklady Biochemistry and Biophysics Pub Date : 2024-03-12 DOI:10.1134/S1607672924700753

L. A. Ovchinnikova, S. S. Dzhelad, T. O. Simaniv, M. N. Zakharova, A. G. Gabibov, Y. A. Lomakin

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Abstract

Multiple sclerosis (MS) is an autoimmune neurodegenerative disease leading to inevitable disability and primarily affecting the young and middle-aged population. Recent studies have shown a direct correlation between the risk of MS development and Epstein–Barr virus (EBV) infection. Analysis of the titer of EBV-specific antibodies among patients with MS and healthy donors among Russian population confirmed that MS is characterized by an increased level of serum IgG binding EBNA-1 (EBV nuclear antigen 1). The number of patients with elevated levels of EBNA-1-specific antibodies does not differ statistically significantly between two groups with diametrically opposite courses of MS: benign MS or highly active MS. It can be assumed that the primary link between EBV and the development of MS is restricted to the initiation of the disease and does not impact its severity.

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多发性硬化症患者血清中的 EBNA-1 抗病毒抗原特异性抗体水平与病情严重程度无关

多发性硬化症（MS）是一种自身免疫性神经退行性疾病，会导致不可避免的残疾，主要影响中青年人群。最近的研究表明，多发性硬化症的发病风险与爱泼斯坦-巴氏病毒（EBV）感染直接相关。对俄罗斯多发性硬化症患者和健康供体的 EBV 特异性抗体滴度分析证实，多发性硬化症的特征是血清中结合 EBNA-1（EBV 核抗原 1）的 IgG 水平升高。EBNA-1特异性抗体水平升高的患者人数在多发性硬化症病程截然相反的两组（良性多发性硬化症或高度活动性多发性硬化症）之间没有明显的统计学差异。可以认为，EB 病毒与多发性硬化症发病之间的主要联系仅限于疾病的起始阶段，而不会影响其严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Doklady Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

1.60

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.