Decreased oxytocin levels related to social cognition impairment in borderline personality disorder

IF 5.3 2区医学 Q1 PSYCHIATRY

Acta Psychiatrica Scandinavica Pub Date : 2024-03-13 DOI:10.1111/acps.13679

Alejandra Galvez-Merlin, José M. López-Villatoro, Pilar de la Higuera-González, Alejandro de la Torre-Luque, Karina McDowell, Marina Díaz-Marsá, Juan C. Leza, José L. Carrasco

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引用次数: 0

Abstract

Introduction

Dysfunctions in the oxytocin system have been reported in patients with borderline personality disorder (BPD). Deficits could be related to interpersonal hypersensitivity, which has been previously associated with failures in social cognition (SC) in this disorder, especially in Theory of Mind (ToM) skills. The aim of this work is to study the links between the oxytocin system and SC impairments in patients with BPD.

Method

Plasma oxytocin levels (OXT) and protein expression of oxytocin receptors in blood mononuclear cells (OXTR) were examined in 33 patients with a diagnosis of BPD (age: M 28.85, DT = 8.83). Social cognition was assessed using the Movie for the Assessment of Social Cognition (MASC). Statistical associations between biochemical factors and different response errors in MASC were analyzed through generalized linear regression controlling for relevant clinical factors.

Results

Generalized linear regression showed a significant relationship between lower OXTR and overmentalization in BPD patients (OR = 0.90).

Conclusions

This work supports the relationship between alterations in the oxytocin system and ToM impairments observed in BPD patients, enhancing the search for endophenotypes related to the phenotypic features of the disorder to improve current clinical knowledge and address more specific therapeutic targets.

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催产素水平下降与边缘型人格障碍的社会认知障碍有关。

简介据报道，边缘型人格障碍（BPD）患者的催产素系统存在功能障碍。这种缺陷可能与人际关系过敏有关，而人际关系过敏以前曾与该障碍患者的社会认知（SC）失败有关，尤其是在心智理论（ToM）技能方面。本研究旨在研究催产素系统与 BPD 患者社交认知障碍之间的联系：方法：对 33 名确诊为 BPD 的患者（年龄：M 28.85，DT = 8.83）进行血浆催产素水平（OXT）和血液单核细胞中催产素受体蛋白表达（OXTR）的检测。社会认知采用社会认知评估模型（MASC）进行评估。通过控制相关临床因素的广义线性回归分析了生化因素与 MASC 不同反应误差之间的统计关联：结果：广义线性回归显示，BPD 患者较低的 OXTR 与过度评估之间存在显著关系（OR = 0.90）：这项工作证实了催产素系统的改变与在 BPD 患者中观察到的 ToM 损伤之间的关系，从而加强了对与该疾病表型特征相关的内表型的研究，以改善当前的临床知识并确定更具体的治疗目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Psychiatrica Scandinavica 医学-精神病学

CiteScore

11.20

自引率

3.00%

发文量

135

审稿时长

6-12 weeks

期刊介绍： Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.